V
Vittoria Mariano
Researcher at University of Lausanne
Publications - 6
Citations - 537
Vittoria Mariano is an academic researcher from University of Lausanne. The author has contributed to research in topics: Internal medicine & Phenotype. The author has an hindex of 4, co-authored 5 publications receiving 221 citations. Previous affiliations of Vittoria Mariano include Katholieke Universiteit Leuven & University of Rome Tor Vergata.
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Journal ArticleDOI
SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Frank Koopmans,Pim van Nierop,Maria Andres-Alonso,Andrea Byrnes,Tony Cijsouw,Marcelo P. Coba,L. Niels Cornelisse,Ryan J. Farrell,Hana L. Goldschmidt,Daniel P. Howrigan,Natasha K. Hussain,Natasha K. Hussain,Cordelia Imig,Arthur P.H. de Jong,Hwajin Jung,Mahdokht Kohansal-Nodehi,Barbara Kramarz,Noa Lipstein,Ruth C. Lovering,Harold D. MacGillavry,Vittoria Mariano,Vittoria Mariano,Huaiyu Mi,Momchil Ninov,David Osumi-Sutherland,Rainer Pielot,Karl-Heinz Smalla,Haiming Tang,Katherine Tashman,Ruud F. Toonen,Chiara Verpelli,Rita Reig-Viader,Kyoko Watanabe,Jan R.T. van Weering,Tilmann Achsel,Tilmann Achsel,Ghazaleh Ashrafi,Nimra Asi,Tyler C. Brown,Pietro De Camilli,Marc Feuermann,Rebecca E. Foulger,Pascale Gaudet,Anoushka Joglekar,Alexandros K. Kanellopoulos,Alexandros K. Kanellopoulos,Robert C. Malenka,Roger A. Nicoll,Camila Pulido,Jaime de Juan-Sanz,Morgan Sheng,Thomas C. Südhof,Hagen Tilgner,Claudia Bagni,Claudia Bagni,Àlex Bayés,Thomas Biederer,Nils Brose,John Jia En Chua,Daniela C. Dieterich,Eckart D. Gundelfinger,Casper C. Hoogenraad,Richard L. Huganir,Richard L. Huganir,Reinhard Jahn,Pascal S. Kaeser,Eunjoon Kim,Michael R. Kreutz,Peter S. McPherson,Neale Bm,Vincent O'Connor,Danielle Posthuma,Timothy A. Ryan,Carlo Sala,Guoping Feng,Steven E. Hyman,Paul Thomas,August B. Smit,Matthijs Verhage +78 more
TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.
Journal ArticleDOI
Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits
Alexandros K. Kanellopoulos,Vittoria Mariano,Vittoria Mariano,Marco Spinazzi,Young Jae Woo,Young Jae Woo,Colin Mclean,Ulrike Pech,Ka Wan Li,J. Douglas Armstrong,J. Douglas Armstrong,Angela Giangrande,Patrick Callaerts,August B. Smit,Brett S. Abrahams,André Fiala,Tilmann Achsel,Claudia Bagni,Claudia Bagni +18 more
TL;DR: It is shown that Drosophila mutants in the homolog of the human CYFIP1, a gene linked to autism and schizophrenia, exhibit mitochondrial hyperactivity and altered group behavior, and Aralar is identified as the mitochondrial transporter that sequesters GABA upon increased mitochondrial activity.
Journal ArticleDOI
Modelling Learning and Memory in Drosophila to Understand Intellectual Disabilities.
TL;DR: How technologies in the fly model, combined with a high degree of molecular and physiological conservation between flies and mammals, highlight the Drosophila system as an ideal model to study neurodevelopmental disorders, from genetics to behavior is discussed.
Journal ArticleDOI
Zebrafish as a translational regeneration model to study the activation of neural stem cells and role of their environment.
TL;DR: Investigating and comparing the neuronal regeneration in zebrafish and mammals may lead to a better understanding of the mechanisms behind neurogenesis, and the failure of the regenerative response in mammals.
Journal ArticleDOI
Maintenance mechanisms of circuit-integrated axons.
Vittoria Mariano,Vittoria Mariano,Nuria Domínguez-Iturza,Nuria Domínguez-Iturza,Lukas J. Neukomm,Claudia Bagni,Claudia Bagni +6 more
TL;DR: In this article, the authors highlight intrinsic and extrinsic mechanisms that ensure the health and survival of axons and discuss examples of mutations associated with impaired axonal maintenance identified in specific neurological conditions.