J
Jaime de Juan-Sanz
Researcher at Cornell University
Publications - 17
Citations - 1213
Jaime de Juan-Sanz is an academic researcher from Cornell University. The author has contributed to research in topics: Glycine transporter & Glycine receptor. The author has an hindex of 11, co-authored 17 publications receiving 726 citations. Previous affiliations of Jaime de Juan-Sanz include Spanish National Research Council & Hospital Universitario La Paz.
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SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Frank Koopmans,Pim van Nierop,Maria Andres-Alonso,Andrea Byrnes,Tony Cijsouw,Marcelo P. Coba,L. Niels Cornelisse,Ryan J. Farrell,Hana L. Goldschmidt,Daniel P. Howrigan,Natasha K. Hussain,Natasha K. Hussain,Cordelia Imig,Arthur P.H. de Jong,Hwajin Jung,Mahdokht Kohansal-Nodehi,Barbara Kramarz,Noa Lipstein,Ruth C. Lovering,Harold D. MacGillavry,Vittoria Mariano,Vittoria Mariano,Huaiyu Mi,Momchil Ninov,David Osumi-Sutherland,Rainer Pielot,Karl-Heinz Smalla,Haiming Tang,Katherine Tashman,Ruud F. Toonen,Chiara Verpelli,Rita Reig-Viader,Kyoko Watanabe,Jan R.T. van Weering,Tilmann Achsel,Tilmann Achsel,Ghazaleh Ashrafi,Nimra Asi,Tyler C. Brown,Pietro De Camilli,Marc Feuermann,Rebecca E. Foulger,Pascale Gaudet,Anoushka Joglekar,Alexandros K. Kanellopoulos,Alexandros K. Kanellopoulos,Robert C. Malenka,Roger A. Nicoll,Camila Pulido,Jaime de Juan-Sanz,Morgan Sheng,Thomas C. Südhof,Hagen Tilgner,Claudia Bagni,Claudia Bagni,Àlex Bayés,Thomas Biederer,Nils Brose,John Jia En Chua,Daniela C. Dieterich,Eckart D. Gundelfinger,Casper C. Hoogenraad,Richard L. Huganir,Richard L. Huganir,Reinhard Jahn,Pascal S. Kaeser,Eunjoon Kim,Michael R. Kreutz,Peter S. McPherson,Neale Bm,Vincent O'Connor,Danielle Posthuma,Timothy A. Ryan,Carlo Sala,Guoping Feng,Steven E. Hyman,Paul Thomas,August B. Smit,Matthijs Verhage +78 more
TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.
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Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages
Ying Wang,Manikandan Subramanian,Manikandan Subramanian,Arif Yurdagul,Valéria C. Barbosa-Lorenzi,Bishuang Cai,Jaime de Juan-Sanz,Timothy A. Ryan,Masatoshi Nomura,Frederick R. Maxfield,Ira Tabas +10 more
TL;DR: Mitochondrial fission in response to AC uptake is a critical process that enables macrophages to clear multiple ACs and to avoid the pathologic consequences of defective efferocytosis in vivo.
Journal ArticleDOI
Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals
Jaime de Juan-Sanz,Graham T Holt,Eric R. Schreiter,Fernando de Juan,Douglas S. Kim,Timothy A. Ryan +5 more
TL;DR: A critical role of presynaptic ER in the control of neurotransmitter release is revealed and will help frame future investigations into the molecular basis of ER-driven neuronal disease states.
Journal ArticleDOI
Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission.
TL;DR: It is shown that synapses can switch from glycolytic to oxidative metabolism, but to do so, they rely on activity-driven presynaptic mitochondrial Ca2+ uptake to accelerate ATP production, and the brain-specific protein MICU3 is identified as a critical driver of this tuning of Ca 2+ sensitivity.
Journal ArticleDOI
Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation.
Lisa M. Weatherly,Andrew J. Nelson,Juyoung Shim,Abigail M. Riitano,Erik D. Gerson,Andrew Hart,Jaime de Juan-Sanz,Timothy A. Ryan,Roger B. Sher,Samuel T. Hess,Julie A. Gosse +10 more
TL;DR: These mechanisms provide partial explanations for triclosan's adverse effects on human reproduction, immunology, and development and the first to utilize super‐resolution microscopy in the field of toxicology.