Hana L. Goldschmidt

TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.

TL;DR: The results indicate that the steric requirements for cytosine deamination are one intrinsic barrier to the proposed function of deaminases in DNA demethylation.

TL;DR: The utility of BioSITe is demonstrated when applied to proximity-dependent labeling methods, APEX and BioID, as well as biotin-based click chemistry strategies for identifying O-GlcNAc-modified sites and the use of isotopically labeled biotin for quantitative BioSITS experiments that simplify differential interactome analysis and obviate the need for metabolic labeling strategies such as SILAC.

TL;DR: The recent understanding of the roles PLDs, DGKs, and DAG lipases, as well as sphingolipids and cholesterol play in synaptic vesicle cycling is reviewed.

TL;DR: A role for DGKθ in the mammalian CNS is reported in facilitating recycling of presynaptic vesicles at excitatory synapses and this data suggest that DGK θ supports synaptic transmission during periods of elevated neuronal activity.