C
Carlos Cordon-Cardo
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 620
Citations - 91832
Carlos Cordon-Cardo is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 144, co-authored 589 publications receiving 84862 citations. Previous affiliations of Carlos Cordon-Cardo include The Rogosin Institute & Erasmus University Rotterdam.
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Journal ArticleDOI
A microRNA polycistron as a potential human oncogene
Lin He,J. Michael Thomson,Michael T. Hemann,Eva Hernando-Monge,David Mu,Summer G. Goodson,Scott Powers,Carlos Cordon-Cardo,Scott W. Lowe,Gregory J. Hannon,Scott M. Hammond +10 more
TL;DR: It is found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in human B-cell lymphomas, and the cluster is implicate as a potential human oncogene.
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A multigenic program mediating breast cancer metastasis to bone.
Yibin Kang,Peter M. Siegel,Weiping Shu,Maria Drobnjak,Sanna M. Kakonen,Carlos Cordon-Cardo,Theresa A. Guise,Theresa A. Guise,Joan Massagué +8 more
TL;DR: Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor.
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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue,Lars Zender,Cornelius Miething,Ross A. Dickins,Ross A. Dickins,Eva Hernando,Valery Krizhanovsky,Carlos Cordon-Cardo,Scott W. Lowe,Scott W. Lowe +9 more
TL;DR: It is indicated that p53 loss can be required for the maintenance of aggressive carcinomas, and illustrates how the cellular senescence program can act together with the innate immune system to potently limit tumour growth.
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Zhenbang Chen,Lloyd C. Trotman,David R. Shaffer,Hui Kuan Lin,Zohar A. Dotan,Masaru Niki,Jason A. Koutcher,Howard I. Scher,Thomas Ludwig,William L. Gerald,Carlos Cordon-Cardo,Pier Paolo Pandolfi +11 more
TL;DR: It is shown that conditional inactivation of Trp53 in the mouse prostate fails to produce a tumour phenotype, whereas complete Pten inactivation in the prostate triggers non-lethal invasive prostate cancer after long latency, and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours.
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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Carlos Cordon-Cardo,James P. O'Brien,Dolors Casals,Lana Rittman-Grauer,June L. Biedler,Myron R. Melamed,Joseph R. Bertino +6 more
TL;DR: P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.