Guey Jen Lee-Chen

TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.

TL;DR: In this article, the authors show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations.

TL;DR: Clinically, all 16 patients carrying a GBA mutation presented with a typical parkinsonian phenotype and experienced a good or excellent response to levodopa and Mutations of the GBA gene may be associated with the development of EOPD in Taiwan.

TL;DR: These findings reveal that both hyperglycemia and intrahippocampal LPS injection induced cognitive dysfunction via activation of NF-κB-related inflammatory responses, and EX-4 might be considered as a potential adjuvant entity to protect against neurodegenerative diseases.

TL;DR: This case expands the current phenotype associated with SCA17, which consisted of progressive ataxia, autonomic dysfunction, parkinsonism, supranuclear palsy and cognitive impairment, and should be considered in the differential diagnosis of cases resembling multiple system atrophy.