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Chad A. Cowan
Researcher at Beth Israel Deaconess Medical Center
Publications - 133
Citations - 21703
Chad A. Cowan is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 47, co-authored 131 publications receiving 19789 citations. Previous affiliations of Chad A. Cowan include Massachusetts Institute of Technology & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
Luigi Warren,Philip D. Manos,Philip D. Manos,Tim Ahfeldt,Tim Ahfeldt,Yuin-Han Loh,Hu Li,Hu Li,Frank H. Lau,Wataru Ebina,Pankaj Mandal,Zachary D. Smith,Alexander Meissner,Alexander Meissner,George Q. Daley,Andrew S. Brack,James J. Collins,James J. Collins,James J. Collins,Chad A. Cowan,Thorsten M. Schlaeger,Thorsten M. Schlaeger,Derrick J. Rossi +22 more
TL;DR: It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.
Journal ArticleDOI
Disease-Specific Induced Pluripotent Stem Cells
In-Hyun Park,Natasha Arora,Hongguang Huo,Nimet Maherali,Tim Ahfeldt,Tim Ahfeldt,Akiko Shimamura,M. William Lensch,M. William Lensch,Chad A. Cowan,Konrad Hochedlinger,George Q. Daley +11 more
TL;DR: The generation of induced pluripotent stem cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance are described, offering an unprecedented opportunity to recapitulate both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development.
Journal ArticleDOI
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Kiran Musunuru,Kiran Musunuru,Kiran Musunuru,Alanna Strong,Maria Frank-Kamenetsky,Noemi E. Lee,Tim Ahfeldt,Tim Ahfeldt,Katherine V. Sachs,Xiaoyu Li,Hui Li,Nicolas Kuperwasser,Vera M. Ruda,James P. Pirruccello,James P. Pirruccello,Brian Muchmore,Ludmila Prokunina-Olsson,Jennifer L. Hall,Jennifer L. Hall,Eric E. Schadt,Carlos R. Morales,Sissel Lund-Katz,Michael C. Phillips,Jamie Wong,William Cantley,Timothy Racie,Kenechi Ejebe,Kenechi Ejebe,Marju Orho-Melander,Olle Melander,Victor Koteliansky,Kevin Fitzgerald,Ronald M. Krauss,Chad A. Cowan,Chad A. Cowan,Sekar Kathiresan,Sekar Kathiresan,Daniel J. Rader +37 more
TL;DR: Functional evidence for a novel regulatory pathway for lipoprotein metabolism is provided and it is suggested that modulation of this pathway may alter risk for MI in humans.
Journal ArticleDOI
Derivation of embryonic stem-cell lines from human blastocysts.
Chad A. Cowan,Irinha Klimanskaya,Jill A. McMahon,Jocelyn Atienza,Jeannine Witmyer,Jacob P. Zucker,Shunping Wang,Cynthia C. Morton,Andrew P. McMahon,Doug Powers,Douglas A. Melton +10 more
TL;DR: The procedures used to develop 17 lines of human embryonic stem cells from the inner cell masses of blastocysts are discussed.
Journal ArticleDOI
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
Manching Ku,Richard Koche,Richard Koche,Richard Koche,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Eric M. Mendenhall,Eric M. Mendenhall,Mitsuhiro Endoh,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Aviva Presser,Aviva Presser,Chad Nusbaum,Xiaohui Xie,Andrew S. Chi,Andrew S. Chi,Mazhar Adli,Mazhar Adli,Simon Kasif,Leon M. Ptaszek,Chad A. Cowan,Eric S. Lander,Eric S. Lander,Haruhiko Koseki,Bradley E. Bernstein +26 more
TL;DR: It is proposed that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells.