Chris McKennan

TL;DR: It is shown that platelet-specific ablation of PIKfyve in mice leads to accelerated arterial thrombosis, and, unexpectedly, also to inappropriate inflammatory responses characterized by macrophage accumulation in multiple tissues.

TL;DR: Upper airway microbial composition in infancy contributes to the development of AR during childhood, and this trajectory is mediated, at least in part, through altered DNAm patterns in upper airway mucosal cells.

TL;DR: In a mouse model of α-synuclein aggregation, 6% of 6215 proteins and 1.6% of 8183 phosphopeptides changed in abundance, indicating conservation of proteostasis and phosphorylation signaling as mentioned in this paper.

TL;DR: This work proves that existing methods to account for unobserved covariates often inflate Type I error, and provides alternative estimators for the coefficients of interest that correct the inflation, and proves that their estimators are asymptotically equivalent to the ordinary least squares estimators obtained when every covariate is observed.

TL;DR: This study suggests that SNPs regulating GSDMB expression in airway epithelial cells have a major role in childhood-onset asthma, whereasSNPs regulating the expression levels of 17q12-21 genes in resting blood cells are not central asthma risk.