Christian Utpatel

TL;DR: HCU contamination with M chimaera at the LivaNova factory seems a likely source for cardiothoracic surgery-related severe M chimeera infections diagnosed in Switzerland, Germany, the Netherlands, the UK, the USA, and Australia.

TL;DR: MTBseq, a bioinformatics pipeline for next-generation genome sequence data analysis of Mycobacterium tuberculosis complex isolates, is presented, employing a reference mapping based workflow and performs a lineage classification based on phylogenetic single nucleotide polymorphisms (SNPs).

TL;DR: The data suggest that source cases are linked to an M tuberculosis clone circulating in northern Somalia or Djibouti and that transmission probably occurred en route before arrival in Europe, and that the shared mutation of tlyA is a drug resistance mutation and phylogenetic marker, the first of its kind in M tuberculosis sensu stricto.

TL;DR: The results suggest that clusters based on Spoligotyping could encompass transmission events that occurred almost 200 years prior to sampling while 24-loci-MIRU-VNTR often represented three decades of transmission.

TL;DR: Standardized protocols for rapid delamanid drug susceptibility testing (DST) using the colorimetric resazurin microtitre assay (REMA) and semi-automated BACTEC MGIT™ 960 system (MGIT) are established by establishing breakpoints that accurately discriminate between susceptibility and resistance of Mycobacterium tuberculosis to Delamanid.