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Christoph Lange
Researcher at Harvard University
Publications - 156
Citations - 2924
Christoph Lange is an academic researcher from Harvard University. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 24, co-authored 154 publications receiving 1952 citations. Previous affiliations of Christoph Lange include University of Bonn & University of Duisburg-Essen.
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Journal ArticleDOI
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Joana P. Bernardes,Neha Mishra,Florian Tran,Thomas Bahmer,Lena Best,Johanna I. Blase,Dora Bordoni,Jeanette Franzenburg,Ulf Geisen,Jonathan Josephs-Spaulding,Philipp Köhler,Axel Künstner,Elisa Rosati,Anna C. Aschenbrenner,Petra Bacher,Nathan Baran,Teide Boysen,Burkhard Brandt,Niklas Bruse,Jonathan Dörr,Andreas Dräger,Gunnar Elke,David Ellinghaus,Julia Fischer,Michael Forster,Andre Franke,Sören Franzenburg,Norbert Frey,Anette Friedrichs,Janina Fuß,Andreas Glück,Jacob Hamm,Finn Hinrichsen,Marc P. Hoeppner,Simon Imm,Ralf Junker,Sina Kaiser,Ying H. Kan,Rainer Knoll,Christoph Lange,Georg Laue,Clemens Lier,Matthias Lindner,Georgios Marinos,Robert Markewitz,Jacob Nattermann,Rainer Noth,Peter Pickkers,Klaus F. Rabe,Alina Renz,Christoph Röcken,Jan Rupp,Annika Schaffarzyk,Alexander Scheffold,Jonas Schulte-Schrepping,Jonas Schulte-Schrepping,Domagoj Schunk,Dirk Skowasch,Thomas Ulas,Thomas Ulas,Klaus-Peter Wandinger,Michael Wittig,Johannes Zimmermann,Hauke Busch,Bimba F. Hoyer,Christoph Kaleta,Jan Heyckendorf,Matthijs Kox,Jan Rybniker,Stefan Schreiber,Joachim L. Schultze,Joachim L. Schultze,Philip Rosenstiel,Nicholas E. Banovich,Tushar J. Desai,Oliver Eickelberg,Muzlifa Haniffa,Peter Horvath,Jonathan A. Kropski,Robert Lafyatis,Joakim Lundeberg,Kerstin B. Meyer,Martijn C. Nawijn,Marko Nikolic,Jose Ordovas Montanes,Dana Pe'er,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Christos Samakovlis,Joachim Schultze,Alex K. Shalek,Douglas P. Shepherd,Jason R. Spence,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Laure-Emmanuelle Zaragosi,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colme-Tatche,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Markus Landthaler,Yang Li,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Niklaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Antoine-Emmanuel Saliba,Leif E. Sander,Birgit Sawitzki,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +165 more
TL;DR: The study demonstrates broad cellular effects of SARS-CoV-2 infection beyond classical immune cells and may serve as an entry point to develop biomarkers and targeted treatments of patients with COVID-19.
Journal ArticleDOI
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary
Charles L. Daley,Jonathan M. Iaccarino,Christoph Lange,Emmanuelle Cambau,Richard J. Wallace,Claire Andrejak,Erik C. Böttger,Jan Brozek,David E. Griffith,Lorenzo Guglielmetti,Lorenzo Guglielmetti,Gwen A. Huitt,Shandra L Knight,Philip Leitman,Theodore K. Marras,Kenneth N. Olivier,Miguel Santin,Jason E. Stout,Enrico Tortoli,Jakko van Ingen,Dirk Wagner,Kevin L. Winthrop +21 more
TL;DR: This guideline focuses on pulmonary disease in adults (without cystic fibrosis or human immunodeficiency virus infection) caused by the most common NTM pathogens such as Mycobacterium avium complex, MycOBacterium kansasii, and Myc Cobacterium xenopi among the slowly growing NTM and MyCobacterius abscessus among the rapidly growing N TM.
Journal ArticleDOI
Family-based association analysis of β2-adrenergic receptor polymorphisms in the childhood asthma management program
Edwin K. Silverman,Edwin K. Silverman,David J. Kwiatkowski,Jody S. Sylvia,Ross Lazarus,Jeffrey M. Drazen,Jeffrey M. Drazen,Christoph Lange,Nan M. Laird,Scott T. Weiss,Scott T. Weiss +10 more
TL;DR: B2AR variants are associated with spirometric values and bronchodilator responsiveness, but different regions of the gene provide evidence for association with these phenotypes.
Journal ArticleDOI
Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Zhiyi Lan,Nafees Ahmad,Parvaneh Baghaei,Linda Barkane,Andrea Benedetti,Sarah K. Brode,Sarah K. Brode,James C.M. Brust,Jonathon R. Campbell,Vicky Chang,Vicky Chang,Dennis Falzon,Lorenzo Guglielmetti,Petros Isaakidis,Russell R. Kempker,Maia Kipiani,Liga Kuksa,Christoph Lange,Rafael Laniado-Laborín,Payam Nahid,Denise Rodrigues,Rupak Singla,Zarir F Udwadia,Dick Menzies,Noor Azlinda Ahmad,P Baghaei,L Barkane,A Benedetti,SK Brode,Jcm Brust,JR Campbell,Vwl Chang,D Falzon,L Guglielmetti,P Isaakidis,RR Kempker,M Kipiani,L Kuksa,Z Lan,Christoph Lange,R Laniado-Laborín,P Nahid,Dafne Paiva Rodrigues,R Singla,Zarir F. Udwadia,D Menzies +45 more
TL;DR: Fluoroquinolones, clofazimine, and bedaquiline had the lowest incidence of adverse events leading to permanent drug discontinuation, whereas second-line injectable drugs, aminosalicylic acid, and linezolid had the highest incidence.
Journal ArticleDOI
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study
Timothy M Walker,Matthias Merker,Astrid M. Knoblauch,Peter Helbling,Otto D. Schoch,Marieke J. van der Werf,Katharina Kranzer,Lena Fiebig,Stefan Kröger,Walter Haas,Harald Hoffmann,Alexander Indra,Adrian Egli,Adrian Egli,Daniela Maria Cirillo,Jérôme Robert,Thomas R. Rogers,Ramona Groenheit,Anne Torunn Mengshoel,Vanessa Mathys,Marjo Haanperä,Dick van Soolingen,Stefan Niemann,Erik C. Böttger,Peter M. Keller,Korkut Avsar,Christoph Bauer,Enos Bernasconi,Emanuele Borroni,Sergio Brusin,Mireia Coscollá Dévis,Derrick W. Crook,Martin Dedicoat,MM Fitzgibbon,Sebastien Gagneux,Francisca Geiger,Jean-Paul Guthmann,David Hendrickx,Sabine Hoffmann-Thiel,Jakko van Ingen,Sarah Jackson,Katia Jaton,Christoph Lange,Jessica Mazza Stalder,Joan O'Donnell,Onya Opota,Tim E. A. Peto,Benjamin Preiswerk,E Roycroft,Mariko Sato,Regina Schacher,Bettina Schulthess,E. Grace Smith,H. Soini,Wladimir Sougakoff,Elisa Tagliani,Christian Utpatel,Nicolas Veziris,Christiane Wagner-Wiening,Mark Witschi +59 more
TL;DR: The data suggest that source cases are linked to an M tuberculosis clone circulating in northern Somalia or Djibouti and that transmission probably occurred en route before arrival in Europe, and that the shared mutation of tlyA is a drug resistance mutation and phylogenetic marker, the first of its kind in M tuberculosis sensu stricto.