C
Christopher Kabrhel
Researcher at Harvard University
Publications - 173
Citations - 5952
Christopher Kabrhel is an academic researcher from Harvard University. The author has contributed to research in topics: Pulmonary embolism & Emergency department. The author has an hindex of 37, co-authored 159 publications receiving 4316 citations. Previous affiliations of Christopher Kabrhel include Brigham and Women's Hospital.
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Journal ArticleDOI
Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism.
TL;DR: The derived eight‐factor block rule reduced the pretest probability below the test threshold for d‐dimer in two validation populations, but the rule's utility was limited by low specificity.
Journal ArticleDOI
Prospective multicenter evaluation of the pulmonary embolism rule‐out criteria
Jeffrey A. Kline,D. M. Courtney,Christopher Kabrhel,Christopher L. Moore,Howard A. Smithline,Michael C. Plewa,Peter B. Richman,Brian J. O'Neil,Kristen E. Nordenholz +8 more
TL;DR: The combination of gestalt estimate of low suspicion for PE and PERC(−) reduces the probability of VTE to below 2% in about 20% of outpatients with suspected PE.
Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal ArticleDOI
Treatment of submassive pulmonary embolism with tenecteplase or placebo: Cardiopulmonary outcomes at 3 months: Multicenter double-blind, placebo-controlled randomized trial
Jeffrey A. Kline,Kristen E. Nordenholz,D. M. Courtney,Christopher Kabrhel,Alan E. Jones,Matthew T. Rondina,Deborah B. Diercks,James R. Klinger,Jackeline Hernandez +8 more
TL;DR: A patient's quality of life can be affected by acute pulmonary embolism due to persistent dyspnea or exercise intolerance, especially if the patient has a history of chronic obstructive pulmonary disease.
Journal ArticleDOI
Interventional Therapies for Acute Pulmonary Embolism: Current Status and Principles for the Development of Novel Evidence: A Scientific Statement From the American Heart Association
Jay Giri,Akhilesh K. Sista,Ido Weinberg,Clive Kearon,Dharam J. Kumbhani,Nimesh D. Desai,Gregory Piazza,Mark T. Gladwin,Saurav Chatterjee,Taisei Kobayashi,Christopher Kabrhel,Geoffrey D. Barnes +11 more
TL;DR: The purpose of this document is to clarify the current state of endovascular interventional therapy for acute PE and to provide considerations for evidence development for new devices that will define which patients with PE would derive the greatest net benefit from their use in various clinical settings.