F
François Cambien
Researcher at Institute of Chartered Accountants of Nigeria
Publications - 6
Citations - 610
François Cambien is an academic researcher from Institute of Chartered Accountants of Nigeria. The author has contributed to research in topics: Population & Linkage disequilibrium. The author has an hindex of 5, co-authored 6 publications receiving 553 citations. Previous affiliations of François Cambien include French Institute of Health and Medical Research & University of Virginia.
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Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal Article
Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis.
TL;DR: Ten new polymorphisms were identified, among which 8 were genotyped in 95 healthy nuclear families, in addition to the I/D polymorphism, which suggests the existence of two quantitative trait loci acting additively on ACE levels.
Journal Article
Testing for association between disease and linked marker loci: a log-linear-model analysis.
TL;DR: The log-linear model offers a stepwise method of identification of the parameters causing the difference between populations, and can be extended to any number of loci, alleles, or populations.
Journal ArticleDOI
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2
Jie Huang,Jennifer E. Huffman,Munekazu Yamkauchi,Stella Trompet,Folkert W. Asselbergs,Folkert W. Asselbergs,Maria Sabater-Lleal,David-Alexandre Trégouët,David-Alexandre Trégouët,Wei-Min Chen,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Marcus E. Kleber,Marcus E. Kleber,So-Youn Shin,Diane M. Becker,Weihong Tang,Abbas Dehghan,Abbas Dehghan,Andrew D. Johnson,Vinh Truong,Vinh Truong,Lasse Folkersen,Qiong Yang,Tiphaine Oudot-Mellkah,Brendan M. Buckley,Jason H. Moore,Frances M K Williams,Harry Campbell,Günther Silbernagel,Veronique Vitart,Igor Rudan,Geoffrey H. Tofler,Gerjan Navis,Anita L. DeStefano,Alan F. Wright,Ming-Huei Chen,Anton J. M. de Craen,Bradford B. Worrall,Alicja R. Rudnicka,Ann Rumley,Ebony Bookman,Bruce M. Psaty,Bruce M. Psaty,Fang Chen,Keith L. Keene,Oscar H. Franco,Bernhard O. Böhm,Bernhard O. Böhm,André G. Uitterlinden,Angela M. Carter,J. Wouter Jukema,Naveed Sattar,Naveed Sattar,Joshua C. Bis,Mohammad Arfan Ikram,Michèle M. Sale,Barbara McKnight,Myriam Fornage,Ian Ford,Kent D. Taylor,P. Eline Slagboom,Wendy L. McArdle,Fang-Chi Hsu,Anders Franco-Cereceda,Alison H. Goodall,Lisa R. Yanek,Karen L. Furie,Mary Cushman,Albert Hofman,Albert Hofman,Jacqueline C.M. Witteman,Aaron R. Folsom,Saonli Basu,Nena Matijevic,Wiek H. van Gilst,James F. Wilson,Rudi G. J. Westendorp,Sekar Kathiresan,Muredach P. Reilly,Russell P. Tracy,Ozren Polasek,Bernhard R. Winkelmann,Peter J. Grant,Hans L. Hillege,François Cambien,David J. Stott,Gordon D.O. Lowe,Tim D. Spector,James B. Meigs,Winfried März,Per Eriksson,Lewis C. Becker,Pierre-Emmanuel Morange,Nicole Soranzo,Scott M. Williams,Caroline Hayward,Pim van der Harst,Anders Hamsten,Charles J. Lowenstein,David P. Strachan,Christopher J. O'Donnell,Christopher J. O'Donnell +103 more
TL;DR: A meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA found no associations of the 3 lead SNPs with coronary artery disease or stroke, and implicate a novel role for STXBP5 and STX2 in regulating tPA release.
Journal ArticleDOI
Aldosterone synthase (CYP11B2) gene polymorphism and cerebral white matter hyperintensities.
P. Verpillat,Annick Alpérovitch,François Cambien,Veronique Besancon,H. Desal,Christophe Tzourio +5 more
TL;DR: The association between aldosterone synthase (CYP11B2) gene polymorphism and white matter hyperintensities seen on cerebral MRI was studied in a population-based sample of 829 individuals aged 63 to 75 years and the T allele was associated with the risk of severe white matterhyperintENSities.