Ramin Monajemi

TL;DR: A genome-scale analysis of differential DNA methylation in whole blood after periconceptional exposure to famine during the Dutch Hunger Winter shows that P-DMRs preferentially occur at regulatory regions, are characterized by intermediate levels ofDNA methylation and map to genes enriched for differential expression during early development.

TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.

TL;DR: Genetic variation in genes involved in the IIS and TM pathways is associated with human longevity, and analysis of gene SNP sets from these pathways indicates that the association is scattered over several genes, while the association of the TM pathway seems to be mainly determined by one gene.

TL;DR: It is demonstrated that imbalanced expression of the paternal and maternal X-chromosomes is common in the general population and that the random nature of the X-inactivation mechanism can be sufficient to explain the imbalance.

TL;DR: The data demonstrate mechanisms that influence the specific dimensions of anxiety and depression and show the value of using dimensional phenotypes on one hand and gene sets on the other hand and analysis of genetic data at the pathway‐level provides more power to detect associations and yield valuable biological insight.