D
Daniel B. Mirel
Researcher at Hoffmann-La Roche
Publications - 24
Citations - 3094
Daniel B. Mirel is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Single-nucleotide polymorphism & Allele. The author has an hindex of 15, co-authored 24 publications receiving 2930 citations. Previous affiliations of Daniel B. Mirel include Harvard University & University of Greifswald.
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Journal ArticleDOI
Risk alleles for multiple sclerosis identified by a genomewide study.
David A. Hafler,Alastair Compston,Stephen Sawcer,Mark J. Daly,Philip L. De Jager,Stacey Gabriel,Daniel B. Mirel,Adrian J. Ivinson,Margaret A. Pericak-Vance,Simon G. Gregory,John D. Rioux,John D. Rioux,Jacob L. McCauley,Lisa F. Barcellos,Lisa F. Barcellos,Bruce A.C. Cree,Stephen L. Hauser +16 more
TL;DR: Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.
Journal ArticleDOI
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Andrea D. Coviello,Robin Haring,Melissa Wellons,Dhananjay Vaidya,Terho Lehtimäki,Sarah Keildson,Kathryn L. Lunetta,Chunyan He,Myriam Fornage,Vasiliki Lagou,Massimo Mangino,N. Charlotte Onland-Moret,Brian H. Chen,Joel Eriksson,Melissa Garcia,Yongmei Liu,Annemarie Koster,Kurt Lohman,Leo-Pekka Lyytikäinen,Ann-Kristin Petersen,Jennifer Prescott,Lisette Stolk,Liesbeth Vandenput,Andrew R. Wood,Wei Vivian Zhuang,Aimo Ruokonen,Anna-Liisa Hartikainen,Anneli Pouta,Stefania Bandinelli,Reiner Biffar,Georg Brabant,David G. Cox,David G. Cox,Yuhui Chen,Steven R. Cummings,Luigi Ferrucci,Marc J. Gunter,Susan E. Hankinson,Susan E. Hankinson,Hannu Martikainen,Albert Hofman,Georg Homuth,Thomas Illig,John-Olov Jansson,Andrew D. Johnson,David Karasik,Magnus Karlsson,Johannes Kettunen,Johannes Kettunen,Douglas P. Kiel,Peter Kraft,Jingmin Liu,Östen Ljunggren,Mattias Lorentzon,M. Maggio,Marcello Ricardo Paulista Markus,Dan Mellström,Iva Miljkovic,Daniel B. Mirel,Sarah C. Nelson,Laure Morin Papunen,Petra H.M. Peeters,Inga Prokopenko,Leslie J. Raffel,Martin Reincke,Alexander P. Reiner,Kathryn M. Rexrode,Fernando Rivadeneira,Stephen M. Schwartz,David S. Siscovick,Nicole Soranzo,Nicole Soranzo,Doris Stöckl,Shelley S. Tworoger,André G. Uitterlinden,André G. Uitterlinden,Carla H. van Gils,Ramachandran S. Vasan,H.-Erich Wichmann,Guangju Zhai,Guangju Zhai,Shalender Bhasin,Martin Bidlingmaier,Stephen J. Chanock,Immaculata De Vivo,Tamara B. Harris,David J. Hunter,Mika Kähönen,Simin Liu,Pamela Ouyang,Tim D. Spector,Yvonne T. van der Schouw,Jorma Viikari,Henri Wallaschofski,Mark I. McCarthy,Timothy M. Frayling,Anna Murray,Steve Franks,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Frank De Jong,Olli T. Raitakari,Alexander Teumer,Claes Ohlsson,Joanne M. Murabito,John R. B. Perry,John R. B. Perry,John R. B. Perry +107 more
TL;DR: Evidence of sex-differentiated genetic influences on sex steroid hormone-binding globulin is found and the importance of considering these features when estimating complex trait variance is highlighted.
Journal ArticleDOI
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
Lu Qi,Marilyn C. Cornelis,Peter Kraft,Kristopher J. Stanya,W. H. Linda Kao,James S. Pankow,Josée Dupuis,Josée Dupuis,Jose C. Florez,Jose C. Florez,Caroline S. Fox,Caroline S. Fox,Guillaume Paré,Guillaume Paré,Qi Sun,Cynthia J. Girman,Cathy C. Laurie,Daniel B. Mirel,Teri A. Manolio,Daniel I. Chasman,Eric Boerwinkle,Paul M. Ridker,David J. Hunter,James B. Meigs,Chih-Hao Lee,Rob M. van Dam,Frank B. Hu +26 more
TL;DR: Analysis of genome-wide association scans in nested case-control samples from two prospective cohort studies suggests that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.
Journal ArticleDOI
High-throughput SNP genotyping by single-tube PCR with Tm-shift primers.
Jun Wang,Karen Chuang,Mandeep K. Ahluwalia,Sarika Patel,Nanette Umblas,Daniel B. Mirel,Russell Higuchi,Soren Germer +7 more
TL;DR: Substantial modifications and improvements are reported to an existing homogenous allele-specific PCR-based SNP genotyping method, making it an attractive new option for researchers engaging in candidate gene studies or following up on genome-wide scans.
Journal ArticleDOI
Gene-Environment Interaction Effects on the Development of Immune Responses in the 1st Year of Life
Sabine Hoffjan,Dan L. Nicolae,Irina Ostrovnaya,Kathy A. Roberg,Michael D. Evans,Daniel B. Mirel,Lori Steiner,Karen Walker,Peter Shult,Ronald E. Gangnon,James E. Gern,Fernando D. Martinez,Robert F. Lemanske,Carole Ober +13 more
TL;DR: Significant gene-environment interactions influencing the early patterning of the immune system and the subsequent development of asthma are identified and highlights the importance of considering environmental risk factors in genetic analyses.