C
Chunyan He
Researcher at Indiana University
Publications - 56
Citations - 4748
Chunyan He is an academic researcher from Indiana University. The author has contributed to research in topics: Menarche & Genome-wide association study. The author has an hindex of 26, co-authored 49 publications receiving 4192 citations. Previous affiliations of Chunyan He include University of California, Riverside & Harvard University.
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Journal ArticleDOI
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
John R. B. Perry,Felix R. Day,Cathy E. Elks,Patrick Sulem,Deborah J. Thompson,Teresa Ferreira,Chunyan He,Daniel I. Chasman,Tõnu Esko,Tõnu Esko,Gudmar Thorleifsson,Eva Albrecht,Wei Ang,Tanguy Corre,Tanguy Corre,Diana L. Cousminer,Bjarke Feenstra,Nora Franceschini,Andrea Ganna,Andrew D. Johnson,Sanela Kjellqvist,Kathryn L. Lunetta,George McMahon,Ilja M. Nolte,Lavinia Paternoster,Eleonora Porcu,Albert V. Smith,Lisette Stolk,Alexander Teumer,Natalia Tšernikova,Emmi Tikkanen,Sheila Ulivi,Erin K. Wagner,Najaf Amin,Laura J. Bierut,Enda M. Byrne,Enda M. Byrne,Jouke-Jan Hottenga,Daniel L. Koller,Massimo Mangino,Tune H. Pers,Tune H. Pers,Tune H. Pers,Laura M. Yerges-Armstrong,Jing Hua Zhao,Irene L. Andrulis,Hoda Anton-Culver,Femke Atsma,Stefania Bandinelli,Matthias W. Beckmann,Javier Benitez,Carl Blomqvist,Stig E. Bojesen,Manjeet K. Bolla,Bernardo Bonanni,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Julie E. Buring,Jenny Chang-Claude,Stephen J. Chanock,Jinhui Chen,Georgia Chenevix-Trench,J. Margriet Collée,Fergus J. Couch,David Couper,Andrea D. Coviello,Angela Cox,Kamila Czene,Adamo Pio D'Adamo,George Davey Smith,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Aida Karina Dieffenbach,Alison M. Dunning,Gudny Eiriksdottir,Johan G. Eriksson,Johan G. Eriksson,Peter A. Fasching,Luigi Ferrucci,Dieter Flesch-Janys,Henrik Flyger,Tatiana Foroud,Lude Franke,Melissa E. Garcia,Montserrat Garcia-Closas,Frank Geller,Eco de Geus,Graham G. Giles,Graham G. Giles,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Vilmundur Gudnason,Pascal Guénel,Suiqun Guo,Per Hall,Ute Hamann,Robin Haring,Catharina A. Hartman,Andrew C. Heath,Albert Hofman,Maartje J. Hooning,John L. Hopper,Frank B. Hu,David J. Hunter,David Karasik,Douglas P. Kiel,Julia A. Knight,Veli-Matti Kosma,Zoltán Kutalik,Zoltán Kutalik,Sandra Lai,Diether Lambrechts,Annika Lindblom,Reedik Mägi,Patrik K. E. Magnusson,Arto Mannermaa,Nicholas G. Martin,Gisli Masson,Patrick F. McArdle,Wendy L. McArdle,Mads Melbye,Mads Melbye,Kyriaki Michailidou,Evelin Mihailov,Lili Milani,Roger L. Milne,Roger L. Milne,Heli Nevanlinna,Patrick Neven,Ellen A. Nohr,Albertine J. Oldehinkel,Ben A. Oostra,Aarno Palotie,Aarno Palotie,Aarno Palotie,Munro Peacock,Nancy L. Pedersen,Paolo Peterlongo,Julian Peto,Paul D.P. Pharoah,Dirkje S. Postma,Anneli Pouta,Anneli Pouta,Katri Pylkäs,Paolo Radice,Susan M. Ring,Fernando Rivadeneira,Antonietta Robino,Lynda M. Rose,Anja Rudolph,Veikko Salomaa,Serena Sanna,David Schlessinger,Marjanka K. Schmidt,Mellissa C. Southey,Ulla Sovio,Ulla Sovio,Meir J. Stampfer,Doris Stöckl,Anna Maria Storniolo,Nicholas J. Timpson,Jonathan Tyrer,Jenny A. Visser,Peter Vollenweider,Henry Völzke,Gérard Waeber,Melanie Waldenberger,Henri Wallaschofski,Qin Wang,Gonneke Willemsen,Robert Winqvist,Bruce H. R. Wolffenbuttel,Margaret J. Wright,Dorret I. Boomsma,Michael J. Econs,Kay-Tee Khaw,Ruth J. F. Loos,Ruth J. F. Loos,Mark I. McCarthy,Grant W. Montgomery,John P. Rice,Elizabeth A. Streeten,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Sven Bergmann,Sven Bergmann,Eric Boerwinkle,Heather A. Boyd,Laura Crisponi,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Erik Ingelsson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Peter Kraft,Debbie A Lawlor,Andres Metspalu,Craig E. Pennell,Paul M. Ridker,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,David P. Strachan,André G. Uitterlinden,Nicholas J. Wareham,Elisabeth Widen,Marek Zygmunt,Anna Murray,Douglas F. Easton,Kari Stefansson,Kari Stefansson,Joanne M. Murabito,Ken K. Ong +220 more
TL;DR: In this article, the authors used genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies and found robust evidence for 123 signals at 106 genomic loci associated with age at menarche.
Journal ArticleDOI
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Cathy E. Elks,John R. B. Perry,Patrick Sulem,Daniel I. Chasman,Nora Franceschini,Chunyan He,Kathryn L. Lunetta,Kathryn L. Lunetta,Jenny A. Visser,Enda M. Byrne,Enda M. Byrne,Diana L. Cousminer,Daniel F. Gudbjartsson,Tõnu Esko,Bjarke Feenstra,Jouke-Jan Hottenga,Daniel L. Koller,Zoltán Kutalik,Zoltán Kutalik,Peng Lin,Massimo Mangino,Mara Marongiu,Patrick F. McArdle,Albert V. Smith,Lisette Stolk,Sophie H. Van Wingerden,Jing Hua Zhao,Eva Albrecht,Tanguy Corre,Erik Ingelsson,Caroline Hayward,Patrik K. E. Magnusson,Erin N. Smith,Erin N. Smith,S. Ulivi,Nicole M. Warrington,Lina Zgaga,Helen Alavere,Najaf Amin,Thor Aspelund,Stefania Bandinelli,Inês Barroso,Gerald S. Berenson,Sven Bergmann,Sven Bergmann,Hannah Blackburn,Eric Boerwinkle,Julie E. Buring,Fabio Busonero,Harry Campbell,Stephen J. Chanock,Wei Chen,Marilyn C. Cornelis,David Couper,Andrea D. Coviello,Pio D'Adamo,Ulf de Faire,Eco J. C. de Geus,Panos Deloukas,Angela Döring,George Davey Smith,Douglas F. Easton,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Aaron R. Folsom,Tatiana Foroud,Melissa E. Garcia,Paolo Gasparini,Frank Geller,Christian Gieger,Vilmundur Gudnason,Per Hall,Susan E. Hankinson,Liana Ferreli,Andrew C. Heath,Dena G. Hernandez,Albert Hofman,Frank B. Hu,Thomas Illig,Marjo-Riitta Järvelin,Andrew D. Johnson,David Karasik,Kay-Tee Khaw,Douglas P. Kiel,Tuomas O. Kilpelänen,Ivana Kolcic,Peter Kraft,Lenore J. Launer,Joop S.E. Laven,Shengxu Li,Jianjun Liu,Daniel Levy,Daniel Levy,Nicholas G. Martin,Wendy L. McArdle,Mads Melbye,Vincent Mooser,Jeffrey C. Murray,Sarah S. Murray,Sarah S. Murray,Mike A. Nalls,Pau Navarro,Mari Nelis,Andy R Ness,Kate Northstone,Ben A. Oostra,Munro Peacock,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alex Parker,Nancy L. Pedersen,Leena Peltonen,Craig E. Pennell,Paul D.P. Pharoah,Ozren Polasek,Andrew S. Plump,Anneli Pouta,Eleonora Porcu,Thorunn Rafnar,John P. Rice,Susan M. Ring,Fernando Rivadeneira,Igor Rudan,Igor Rudan,Cinzia Sala,Veikko Salomaa,Serena Sanna,David Schlessinger,Nicholas J. Schork,Nicholas J. Schork,Angelo Scuteri,Ayellet V. Segrè,Ayellet V. Segrè,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Sathanur R. Srinivasan,David P. Strachan,Mar Liis Tammesoo,Emmi Tikkanen,Emmi Tikkanen,Daniela Toniolo,Kim Tsui,Laufey Tryggvadottir,Tyrer Jp,Manuela Uda,Rob M. van Dam,Rob M. van Dam,Joyce B. J. van Meurs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,Michael N. Weedon,H.-Erich Wichmann,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Lauren Young,Guangju Zhai,Wei Vivian Zhuang,Laura J. Bierut,Dorret I. Boomsma,Heather A. Boyd,Laura Crisponi,Ellen W. Demerath,Cornelia M. van Duijn,Michael J. Econs,Tamara B. Harris,David J. Hunter,David J. Hunter,Ruth J. F. Loos,Andres Metspalu,Grant W. Montgomery,Paul M. Ridker,Tim D. Spector,Elizabeth A. Streeten,Kari Stefansson,Kari Stefansson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,Elisabeth Widen,Joanne M. Murabito,Joanne M. Murabito,Ken K. Ong,Ken K. Ong,Anna Murray +196 more
TL;DR: A meta-analysis of 32 genome-wide association studies in 87,802 women of European descent found 30 new menarche loci and found suggestive evidence for a further 10 loci, including four previously associated with body mass index and three in or near genes implicated in hormonal regulation.
Journal ArticleDOI
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
Felix R. Day,Deborah J. Thompson,Hannes Helgason,Hannes Helgason,Daniel I. Chasman,Hilary K. Finucane,Hilary K. Finucane,Patrick Sulem,Katherine S. Ruth,Sean Whalen,Abhishek Sarkar,Abhishek Sarkar,Eva Albrecht,Elisabeth Altmaier,Marzyeh Amini,Caterina Barbieri,Thibaud Boutin,Archie Campbell,Ellen W. Demerath,Ayush Giri,Chunyan He,Jouke J. Hottenga,Robert Karlsson,Ivana Kolcic,Po-Ru Loh,Po-Ru Loh,Kathryn L. Lunetta,Kathryn L. Lunetta,Massimo Mangino,Massimo Mangino,Brumat Marco,George McMahon,Sarah E. Medland,Ilja M. Nolte,Raymond Noordam,Teresa Nutile,Lavinia Paternoster,Natalia Perjakova,Eleonora Porcu,Lynda M. Rose,Katharina E. Schraut,Ayellet V. Segrè,Albert V. Smith,Lisette Stolk,Alexander Teumer,Irene L. Andrulis,Stefania Bandinelli,Matthias W. Beckmann,Javier Benitez,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Stig E. Bojesen,Manjeet K. Bolla,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Linda Broer,Thomas Brüning,Julie E. Buring,Harry Campbell,Eulalia Catamo,Stephen J. Chanock,Georgia Chenevix-Trench,Tanguy Corre,Tanguy Corre,Fergus J. Couch,Diana L. Cousminer,Angela Cox,Laura Crisponi,Kamila Czene,George Davey Smith,Eco J. C. de Geus,Renée de Mutsert,Immaculata De Vivo,Joe Dennis,Peter Devilee,Isabel dos-Santos-Silva,Alison M. Dunning,Johan G. Eriksson,Peter A. Fasching,Peter A. Fasching,Lindsay Fernández-Rhodes,Luigi Ferrucci,Dieter Flesch-Janys,Lude Franke,Marike Gabrielson,Ilaria Gandin,Graham G. Giles,Graham G. Giles,Harald Grallert,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Pascal Guénel,Per Hall,Emily Hallberg,Ute Hamann,Tamara B. Harris,Catharina A. Hartman,Gerardo Heiss,Maartje J. Hooning,John L. Hopper,Frank B. Hu,David J. Hunter,M. Arfan Ikram,Hae Kyung Im,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Peter K. Joshi,David Karasik,Manolis Kellis,Manolis Kellis,Zoltán Kutalik,Zoltán Kutalik,Genevieve Lachance,Diether Lambrechts,Claudia Langenberg,Lenore J. Launer,Joop S.E. Laven,Stefania Lenarduzzi,Jingmei Li,Penelope A. Lind,Sara Lindström,Yongmei Liu,Jian'an Luan,Reedik Mägi,Arto Mannermaa,Hamdi Mbarek,Mark I. McCarthy,Christa Meisinger,Thomas Meitinger,Cristina Menni,Andres Metspalu,Kyriaki Michailidou,Kyriaki Michailidou,Lili Milani,Roger L. Milne,Roger L. Milne,Grant W. Montgomery,Anna Marie Mulligan,Mike A. Nalls,Pau Navarro,Heli Nevanlinna,Dale R. Nyholt,Albertine J. Oldehinkel,Tracy A. O'Mara,Sandosh Padmanabhan,Aarno Palotie,Nancy L. Pedersen,Annette Peters,Julian Peto,Paul D.P. Pharoah,Anneli Pouta,Paolo Radice,Iffat Rahman,Susan M. Ring,Antonietta Robino,Frits R. Rosendaal,Igor Rudan,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Cinzia Sala,Marjanka K. Schmidt,Robert A. Scott,Mitul Shah,Rossella Sorice,Melissa C. Southey,Ulla Sovio,Ulla Sovio,Meir J. Stampfer,Maristella Steri,Konstantin Strauch,Toshiko Tanaka,Emmi Tikkanen,Nicholas J. Timpson,Michela Traglia,Thérèse Truong,Jonathan Tyrer,André G. Uitterlinden,Digna R. Velez Edwards,Veronique Vitart,Uwe Völker,Peter Vollenweider,Qin Wang,Elisabeth Widen,Ko Willems van Dijk,Gonneke Willemsen,Robert Winqvist,Bruce H. R. Wolffenbuttel,Jing Hua Zhao,Magdalena Zoledziewska,Marek Zygmunt,Behrooz Z. Alizadeh,Dorret I. Boomsma,Marina Ciullo,Francesco Cucca,Tõnu Esko,Tõnu Esko,Nora Franceschini,Christian Gieger,Vilmundur Gudnason,Caroline Hayward,Peter Kraft,Debbie A Lawlor,Patrik K. E. Magnusson,Nicholas G. Martin,Dennis O. Mook-Kanamori,Ellen A. Nohr,Ozren Polasek,David J. Porteous,Alkes L. Price,Alkes L. Price,Alkes L. Price,Paul M. Ridker,Harold Snieder,Tim D. Spector,Doris Stöckl,Daniela Toniolo,Sheila Ulivi,Jenny A. Visser,Henry Völzke,Nicholas J. Wareham,James F. Wilson,Amanda B. Spurdle,Unnur Thorsteindottir,Unnur Thorsteindottir,Katherine S. Pollard,Katherine S. Pollard,Douglas F. Easton,Joyce Y. Tung,Jenny Chang-Claude,Jenny Chang-Claude,David A. Hinds,Anna Murray,Joanne M. Murabito,Joanne M. Murabito,Kari Stefansson,Kari Stefansson,Ken K. Ong,John R. B. Perry +244 more
TL;DR: In this article, the authors used 1000 Genomes Project-imputed genotype data in up to ∼370,000 women to identify 389 independent signals (P < 5 × 10-8) for age at menarche, a milestone in female pubertal development.
Journal ArticleDOI
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
Chunyan He,Peter Kraft,Constance Chen,Julie E. Buring,Guillaume Paré,Susan E. Hankinson,Stephen J. Chanock,Paul M. Ridker,David J. Hunter,David J. Hunter,Daniel I. Chasman +10 more
TL;DR: A joint analysis of two genome-wide association studies of these two traits in a total of 17,438 women found 13 associated SNPs clustered at 20p12.3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 ( in or near genes UIMC1 and HK3).
Journal ArticleDOI
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Lisette Stolk,John R. B. Perry,John R. B. Perry,Daniel I. Chasman,Chunyan He,Massimo Mangino,Patrick Sulem,Maja Barbalić,Linda Broer,Enda M. Byrne,Florian Ernst,Tmu Esko,Nora Franceschini,Daniel F. Gudbjartsson,Jouke-Jan Hottenga,Peter Kraft,Peter Kraft,Patrick F. McArdle,Eleonora Porcu,So-Youn Shin,Albert V. Smith,Sophie H. Van Wingerden,Guangju Zhai,Guangju Zhai,Wei V. Zhuang,Eva Albrecht,Behrooz Z. Alizadeh,Thor Aspelund,Stefania Bandinelli,Lovorka Barać Lauc,Jacques S. Beckmann,Mladen Boban,Eric Boerwinkle,Frank J.M. Broekmans,Andrea Burri,Harry Campbell,Stephen J. Chanock,Constance Chen,Marilyn C. Cornelis,Tanguy Corre,Andrea D. Coviello,Pio D'Adamo,Gail Davies,Ulf de Faire,Eco J. C. de Geus,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Shah Ebrahim,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Bart C.J.M. Fauser,Liana Ferreli,Luigi Ferrucci,Krista Fischer,Aaron R. Folsom,Melissa E. Garcia,Paolo Gasparini,Christian Gieger,Nicole L. Glazer,Diederick E. Grobbee,Per Hall,Toomas Haller,Susan E. Hankinson,Merli Hass,Caroline Hayward,Andrew C. Heath,Albert Hofman,Erik Ingelsson,A. Cecile J.W. Janssens,Andrew D. Johnson,David Karasik,David Karasik,Sharon L.R. Kardia,Jules J. Keyzer,Douglas P. Kiel,Douglas P. Kiel,Ivana Kolcic,Z. Kutalik,Z. Kutalik,Jari Lahti,Sandra Lai,Triin Laisk,Joop S.E. Laven,Debbie A Lawlor,Jianjun Liu,Lorna M. Lopez,Yvonne V. Louwers,Patrik K. E. Magnusson,Mara Marongiu,Nicholas G. Martin,Irena Martinović Klarić,Corrado Masciullo,Barbara McKnight,Sarah E. Medland,David Melzer,Vincent Mooser,Pau Navarro,Anne B. Newman,Dale R. Nyholt,N. Charlotte Onland-Moret,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alexander N. Parker,Nancy L. Pedersen,Petra H.M. Peeters,Giorgio Pistis,Andrew S. Plump,Ozren Polasek,Victor J M Pop,Bruce M. Psaty,Bruce M. Psaty,Katri R Currency Signikkönen,Emil Rehnberg,Jerome I. Rotter,Igor Rudan,Igor Rudan,Cinzia Sala,Andres Salumets,Angelo Scuteri,Andrew B. Singleton,Jennifer A. Smith,Harold Snieder,Nicole Soranzo,Nicole Soranzo,Simon N. Stacey,John M. Starr,Maria G. Stathopoulou,Kathleen Stirrups,Ronald P. Stolk,Unnur Styrkarsdottir,Yan V. Sun,Albert Tenesa,Barbara Thorand,Daniela Toniolo,Laufey Tryggvadottir,Kim Tsui,Sheila Ulivi,Rob M. van Dam,Rob M. van Dam,Yvonne T. van der Schouw,Carla H. van Gils,Peter Van Nierop,Jacqueline M. Vink,Peter M. Visscher,Peter M. Visscher,Marlies Voorhuis,Gérard Waeber,Henri Wallaschofski,H.-Erich Wichmann,Elisabeth Widen,Colette J M Wijnands-van Gent,Gonneke Willemsen,James F. Wilson,Bruce H. R. Wolffenbuttel,Alan F. Wright,Laura M. Yerges-Armstrong,Tatijana Zemunik,Lina Zgaga,Lina Zgaga,M. Carola Zillikens,Marek Zygmunt,Alice M. Arnold,Dorret I. Boomsma,Julie E. Buring,Laura Crisponi,Ellen W. Demerath,Ellen W. Demerath,Vilmundur Gudnason,Tamara B. Harris,Frank B. Hu,David J. Hunter,David J. Hunter,Lenore J. Launer,Andres Metspalu,Grant W. Montgomery,Ben A. Oostra,Paul M. Ridker,Serena Sanna,David Schlessinger,Tim D. Spector,Kari Stefansson,Kari Stefansson,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Manuela Uda,André G. Uitterlinden,Cornelia M. van Duijn,Henry Völzke,Anna Murray,Anna Murray,Joanne M. Murabito,Jenny A. Visser,Jenny A. Visser,Kathryn L. Lunetta,Kathryn L. Lunetta +198 more
TL;DR: A meta-analysis of 22 genome-wide association studies in 38,968 women of European descent identified 13 loci newly associated with age at natural menopause, including genes implicated in DNA repair, immune function and immune function.