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Marcello Ricardo Paulista Markus
Researcher at Greifswald University Hospital
Publications - 88
Citations - 2532
Marcello Ricardo Paulista Markus is an academic researcher from Greifswald University Hospital. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 22, co-authored 73 publications receiving 2057 citations. Previous affiliations of Marcello Ricardo Paulista Markus include University of Lübeck & Uppsala University.
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Journal ArticleDOI
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed,Mark Eijgelsheim,Tõnu Esko,Bianca J. J. M. Brundel,David S. Peal,David M. Evans,Ilja M. Nolte,Ayellet V. Segrè,Hilma Holm,Robert E. Handsaker,Harm-Jan Westra,Toby Johnson,Aaron Isaacs,Jian Yang,Alicia Lundby,Jing Hua Zhao,Young Jin Kim,Min Jin Go,Peter Almgren,Murielle Bochud,Gabrielle Boucher,Marilyn C. Cornalis,Daniel F. Gudbjartsson,David Hadley,Pim van der Harst,Caroline Hayward,Martin den Heijer,Wilmar Igl,Anne U. Jackson,Zoltán Kutalik,Jian'an Luan,John P. Kemp,Kati Kristiansson,Claes Ladenvall,Mattias Lorentzon,May E. Montasser,Omer T. Njajou,Paul F. O'Reilly,Sandosh Padmanabhan,Beate St Pourcain,Tuomo Rankinen,Perttu Salo,Toshiko Tanaka,Nicholas J. Timpson,Veronique Vitart,Lindsay L. Waite,William Wheeler,Weihua Zhang,Harmen H.M. Draisma,Mary F. Feitosa,Kathleen F. Kerr,Penelope A. Lind,Evelin Mihailov,N. Charlotte Onland-Moret,Ci Song,Michael N. Weedon,Weijia Xie,Loic Yengo,Devin Absher,Christine M. Albert,Alvaro Alonso,Dan E. Arking,Paul I.W. de Bakker,Beverley Balkau,Cristina Barlassina,Paola Benaglio,Joshua C. Bis,Nabila Bouatia-Naji,Soren Brage,Stephen J. Chanock,Peter S. Chines,Mina K. Chung,Dawood Darbar,Christian Dina,Marcus Dörr,Paul Elliott,Stephan B. Felix,Krista Fischer,Christian Fuchsberger,Eco J. C. de Geus,Philippe Goyette,Vilmundur Gudnason,Tamara B. Harris,Anna-Liisa Hartikainen,Aki S. Havulinna,Susan R. Heckbert,Andrew A. Hicks,Albert Hofman,Suzanne Holewijn,Femke Hoogstra-Berends,Jouke-Jan Hottenga,Majken K. Jensen,Åsa Johansson,Juhani Junttila,Stefan Kääb,Bart Kanon,Shamika Ketkar,Kay-Tee Khaw,Joshua W. Knowles,Angad S. Kooner,Jan A. Kors,Meena Kumari,Lili Milani,Päivi Laiho,Edward G. Lakatta,Claudia Langenberg,Maarten Leusink,Yongmei Liu,Robert Luben,Kathryn L. Lunetta,Stacey N. Lynch,Marcello Ricardo Paulista Markus,Pedro Marques-Vidal,Irene Mateo Leach,Wendy L. McArdle,Steven A. McCarroll,Sarah E. Medland,Kathryn Miller,Grant W. Montgomery,Alanna C. Morrison,Martina Müller-Nurasyid,Pau Navarro,Mari Nelis,Jeffrey R. O'Connell,Christopher J. O'Donnell,Ken K. Ong,Anne B. Newman,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Bruce M. Psaty,Dabeeru C. Rao,Susan M. Ring,Elizabeth J. Rossin,Diana Rudan,Serena Sanna,Robert A. Scott,Jaban S. Sehmi,Stephen J. Sharp,Jordan T. Shin,Andrew B. Singleton,Albert V. Smith,Nicole Soranzo,Tim D. Spector,Chip Stewart,Heather M. Stringham,Kirill V. Tarasov,André G. Uitterlinden,Liesbeth Vandenput,Shih-Jen Hwang,John Whitfield,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Jacqueline C. M. Witteman,Andrew Wong,Quenna Wong,Yalda Jamshidi,Paavo Zitting,Jolanda M. A. Boer,Dorret I. Boomsma,Ingrid B. Borecki,Cornelia M. van Duijn,Ulf Ekelund,Nita G. Forouhi,Philippe Froguel,Aroon D. Hingorani,Erik Ingelsson,Mika Kivimäki,Richard A. Kronmal,Diana Kuh,Lars Lind,Nicholas G. Martin,Ben A. Oostra,Nancy L. Pedersen,Thomas Quertermous,Jerome I. Rotter,Yvonne T. van der Schouw,W. M. Monique Verschuren,Mark Walker,Demetrius Albanes,David O. Arnar,Themistocles L. Assimes,Stefania Bandinelli,Michael Boehnke,Rudolf A. de Boer,Claude Bouchard,L Mark Caulfield W L Mark Caulfield,John C. Chambers,Gary C. Curhan,Daniele Cusi,Johan G. Eriksson,Luigi Ferrucci,Wiek H. van Gilst,Nicola Glorioso,Jacqueline de Graaf,Leif Groop,Ulf Gyllensten,Wen Chi Hsueh,Frank B. Hu,Heikki V. Huikuri,David J. Hunter,Carlos Iribarren,Bo Isomaa,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Lambertus A. Kiemeney,Melanie M. van der Klauw,Jaspal S. Kooner,Peter Kraft,Licia Iacoviello,Terho Lehtimäki,Marja-Liisa Lokki,Braxton D. Mitchell,Gerjan Navis,Markku S. Nieminen,Claes Ohlsson,Neil Poulter,Lu Qi,Olli T. Raitakari,Eric B. Rimm,John D. Rioux,Federica Rizzi,Igor Rudan,Veikko Salomaa,Peter S. Sever,Denis C. Shields,Alan R. Shuldiner,Juha Sinisalo,Alice Stanton,Ronald P. Stolk,David P. Strachan,Jean-Claude Tardif,Unnur Thorsteinsdottir,J. Tuomilehto,Dirk J. van Veldhuisen,Jarmo Virtamo,Jorma Viikari,Peter Vollenweider,Gérard Waeber,Elisabeth Widen,Yoon Shin Cho,Jesper V. Olsen,Peter M. Visscher,Cristen J. Willer,Lude Franke,Jeanette Erdmann,John R. Thompson,Arne Pfeufer,Nona Sotoodehnia,Christopher Newton-Cheh,Patrick T. Ellinor,Bruno H. Stricker,Andres Metspalu,Markus Perola,Jacques S. Beckmann,George Davey Smith,Kari Stefansson,Nicholas J. Wareham,Patricia B. Munroe,Ody C. M. Sibon,David J. Milan,Harold Snieder,Nilesh J. Samani,Ruth J. F. Loos +267 more
TL;DR: A 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci, providing fresh insights into the mechanisms regulating heart rate.
Journal ArticleDOI
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Lia Crotti,Pim van der Harst,Patricia B. Munroe,Tamara T. Koopmann,Nona Sotoodehnia,Elizabeth J. Rossin,Elizabeth J. Rossin,Michael Morley,Xinchen Wang,Xinchen Wang,Andrew D. Johnson,Alicia Lundby,Alicia Lundby,Daniel F. Gudbjartsson,Peter A. Noseworthy,Peter A. Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M. Lahtinen,Ilja M. Nolte,Albert V. Smith,Joshua C. Bis,Aaron Isaacs,Stephen Newhouse,Daniel S. Evans,Wendy S. Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A. Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J. Tester,Stéphanie Chatel,Stefan Gustafsson,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa Torinsson Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G. Panayiotou,María Dolores Torres,Michael Knoflach,Jaroslav A. Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Runjun D. Kumar,Tamara B. Harris,Lenore J. Launer,Alan R. Shuldiner,Alan R. Shuldiner,Alvaro Alonso,Joel S. Bader,Georg Ehret,Hailiang Huang,Hailiang Huang,W. H. Linda Kao,James B. Strait,Peter W. Macfarlane,Morris Brown,Mark J. Caulfield,Nilesh J. Samani,Florian Kronenberg,Johann Willeit,J. Gustav Smith,J. Gustav Smith,J. Gustav Smith,Karin Halina Greiser,Karin Halina Greiser,Henriette E. Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Ivana Kolcic,Ozren Polasek,Alan F. Wright,Maura Griffin,Mark J. Daly,Mark J. Daly,David O. Arnar,Hilma Holm,Unnur Thorsteinsdottir,Joshua C. Denny,Dan M. Roden,Rebecca L. Zuvich,Valur Emilsson,Andrew S. Plump,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Xiaoyan Yin,Xiaoyan Yin,Marco Bobbo,Adamo Pio D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R. Cummings,Mike A. Nalls,Antti Jula,Kimmo Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Markus Perola,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M. Nöthen,Marcel den Hoed,Marcel den Hoed,Ruth J. F. Loos,Ruth J. F. Loos,Dag S. Thelle,Dag S. Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F. Sinner,Melanie Waldenberger,Rudolf A. de Boer,Lude Franke,Pieter A. van der Vleuten,Britt M. Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A.M. Wilde,Elijah R. Behr,Chrysoula Dalageorgou,John R. Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M. Hamilton,Stephen W. Scherer,Jeffrey Brandimarto,Kenneth B. Margulies,Christine E. Moravec,Fabiola Del Greco M,Christian Fuchsberger,Jeffrey R. O'Connell,Wai K. Lee,Graham Watt,Harry Campbell,Sarah H Wild,Nour Eddine El Mokhtari,Norbert Frey,Folkert W. Asselbergs,Folkert W. Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P. van den Berg,Dirk J. van Veldhuisen,Manolis Kellis,Manolis Kellis,Bouwe P. Krijthe,Oscar H. Franco,Albert Hofman,Jan A. Kors,André G. Uitterlinden,Jacqueline C.M. Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A. Oostra,Gonçalo R. Abecasis,Edward G. Lakatta,Antonella Mulas,Marco Orru,David Schlessinger,Manuela Uda,Marcello Ricardo Paulista Markus,Uwe Völker,Harold Snieder,Tim D. Spector,Johan Ärnlöv,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimäki,Mika Kähönen,Nina Mononen,Olli T. Raitakari,Jorma S. A. Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N. Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F. Dominiczak,Fredrik Nyberg,Fredrik Nyberg,Peter H. Whincup,Aroon D. Hingorani,Jean-Jacques Schott,Connie R. Bezzina,Erik Ingelsson,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini,James F. Wilson,Igor Rudan,Andre Franke,Thomas W. Mühleisen,Peter P. Pramstaller,Terho Lehtimäki,Andrew D. Paterson,Afshin Parsa,Yongmei Liu,Cornelia M. van Duijn,David S. Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B. Felix,Serena Sanna,Marylyn D. Ritchie,Bruno H. Stricker,Kari Stefansson,Laurie A. Boyer,Thomas P. Cappola,Jesper V. Olsen,Kasper Lage,Peter J. Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J. Ackerman,Arne Pfeufer,Paul I.W. de Bakker,Christopher Newton-Cheh,Christopher Newton-Cheh +260 more
TL;DR: In this paper, the authors identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.
Journal ArticleDOI
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Andrea D. Coviello,Robin Haring,Melissa Wellons,Dhananjay Vaidya,Terho Lehtimäki,Sarah Keildson,Kathryn L. Lunetta,Chunyan He,Myriam Fornage,Vasiliki Lagou,Massimo Mangino,N. Charlotte Onland-Moret,Brian H. Chen,Joel Eriksson,Melissa Garcia,Yongmei Liu,Annemarie Koster,Kurt Lohman,Leo-Pekka Lyytikäinen,Ann-Kristin Petersen,Jennifer Prescott,Lisette Stolk,Liesbeth Vandenput,Andrew R. Wood,Wei Vivian Zhuang,Aimo Ruokonen,Anna-Liisa Hartikainen,Anneli Pouta,Stefania Bandinelli,Reiner Biffar,Georg Brabant,David G. Cox,David G. Cox,Yuhui Chen,Steven R. Cummings,Luigi Ferrucci,Marc J. Gunter,Susan E. Hankinson,Susan E. Hankinson,Hannu Martikainen,Albert Hofman,Georg Homuth,Thomas Illig,John-Olov Jansson,Andrew D. Johnson,David Karasik,Magnus Karlsson,Johannes Kettunen,Johannes Kettunen,Douglas P. Kiel,Peter Kraft,Jingmin Liu,Östen Ljunggren,Mattias Lorentzon,M. Maggio,Marcello Ricardo Paulista Markus,Dan Mellström,Iva Miljkovic,Daniel B. Mirel,Sarah C. Nelson,Laure Morin Papunen,Petra H.M. Peeters,Inga Prokopenko,Leslie J. Raffel,Martin Reincke,Alexander P. Reiner,Kathryn M. Rexrode,Fernando Rivadeneira,Stephen M. Schwartz,David S. Siscovick,Nicole Soranzo,Nicole Soranzo,Doris Stöckl,Shelley S. Tworoger,André G. Uitterlinden,André G. Uitterlinden,Carla H. van Gils,Ramachandran S. Vasan,H.-Erich Wichmann,Guangju Zhai,Guangju Zhai,Shalender Bhasin,Martin Bidlingmaier,Stephen J. Chanock,Immaculata De Vivo,Tamara B. Harris,David J. Hunter,Mika Kähönen,Simin Liu,Pamela Ouyang,Tim D. Spector,Yvonne T. van der Schouw,Jorma Viikari,Henri Wallaschofski,Mark I. McCarthy,Timothy M. Frayling,Anna Murray,Steve Franks,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Frank De Jong,Olli T. Raitakari,Alexander Teumer,Claes Ohlsson,Joanne M. Murabito,John R. B. Perry,John R. B. Perry,John R. B. Perry +107 more
TL;DR: Evidence of sex-differentiated genetic influences on sex steroid hormone-binding globulin is found and the importance of considering these features when estimating complex trait variance is highlighted.
Journal ArticleDOI
The Aging Process of the Heart: Obesity Is the Main Risk Factor for Left Atrial Enlargement During Aging: The MONICA/KORA (Monitoring of Trends and Determinations in Cardiovascular Disease/Cooperative Research in the Region of Augsburg) Study
Jan Stritzke,Marcello Ricardo Paulista Markus,Marcello Ricardo Paulista Markus,Marcello Ricardo Paulista Markus,Stefanie Duderstadt,Wolfgang Lieb,Andreas Luchner,Angela Döring,Ulrich Keil,Hans-Werner Hense,Heribert Schunkert,Monica,Kora Investigators +12 more
TL;DR: In the general population, obesity appears to be the most important risk factor for left atrial enlargement, and early interventions, especially in young obese individuals, are essential to prevent premature onset of cardiac remodeling at the atrial level.
Journal ArticleDOI
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies
Ganesh Chauhan,Corey R. Arnold,Audrey Y. Chu,Myriam Fornage,Azadeh Reyahi,Joshua C. Bis,Aki S. Havulinna,Muralidharan Sargurupremraj,Albert V. Smith,Hieab H.H. Adams,Seung Hoan Choi,Sara L. Pulit,Stella Trompet,Melissa E. Garcia,Ani Manichaikul,Alexander Teumer,Stefan Gustafsson,Traci M. Bartz,Céline Bellenguez,Jean-Sébastien Vidal,Xueqiu Jian,Olafur Kjartansson,Kerri L. Wiggins,Claudia L. Satizabal,Flora Xue,Samuli Ripatti,Yongmei Liu,Joris Deelen,Marcel den Hoed,Steve Bevan,Jemma C. Hopewell,Rainer Malik,Susan R. Heckbert,Kenneth Rice,Nicholas L. Smith,Christopher R Levi,Pankaj Sharma,Cathie Sudlow,Ali Moussavi Nik,John W. Cole,Reinhold E. Schmidt,James F. Meschia,Vincent Thijs,Arne Lindgren,Olle Melander,Raji P. Grewal,Ralph L. Sacco,Tatjana Rundek,Peter M. Rothwell,Donna K. Arnett,Christina Jern,Julie A. Johnson,Oscar R. Benavente,Sylvia Wassertheil-Smoller,Jin-Moo Lee,Quenna Wong,Hugo J. Aparicio,Stefan T. Engelter,Manja Kloss,Didier Leys,Alessandro Pezzini,Julie E. Buring,Paul M. Ridker,Claudine Berr,Jean-François Dartigues,Anders Hamsten,Patrik K. E. Magnusson,Matthew Traylor,Nancy L. Pedersen,Lars Lannfelt,Lars Lindgren,Cecilia M. Lindgren,Andrew P. Morris,Jordi Jimenez-Conde,Joan Montaner,Farid Radmanesh,Agnieszka Slowik,Daniel Woo,Albert Hofman,Peter J. Koudstaal,Marileen L.P. Portegies,André G. Uitterlinden,Anton J. M. de Craen,Ian Ford,J. Wouter Jukema,David J. Stott,Norrina B. Allen,Michèle M. Sale,Andrew D. Johnson,David A. Bennett,Philip L. De Jager,Charles C. White,Hans J. Grabe,Marcello Ricardo Paulista Markus,Ulf Schminke,Giorgio B. Boncoraglio,Robert Clarke,Yoichiro Kamatani,Jean Dallongeville,Oscar L. Lopez,Jerome I. Rotter,Mike A. Nalls,Rebecca F. Gottesman,Michael Griswold,David S. Knopman,B. Gwen Windham,Alexa S. Beiser,Hugh S. Markus,Erkki Vartiainen,Curtis R. French,Martin Dichgans,Tomi Pastinen,Mark Lathrop,Vilmundur Gudnason,Tobias Kurth,Bruce M. Psaty,Tamara B. Harris,Stephen S. Rich,Anita L. DeStefano,Carsten Oliver Schmidt,Bradford B. Worrall,Jonathan Rosand,Veikko Salomaa,Thomas H. Mosley,Erik Ingelsson,Cornelia M. van Duijn,Christophe Tzourio,Kathryn M. Rexrode,Ordan J. Lehmann,Lenore J. Launer,M. Arfan Ikram,Peter Carlsson,Daniel I. Chasman,Sarah J. Childs,William T. Longstreth,Sudha Seshadri,Stéphanie Debette +136 more
TL;DR: Empirical and experimental data suggest that FOXF2 mediates this association, potentially via differentiation defects of cerebral vascular mural cells, and further expression studies in appropriate human tissues are needed to fully understand the underlying mechanisms.