D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events
Sekar Kathiresan,Olle Melander,Dragi Anevski,Candace Guiducci,Noël P. Burtt,Charlotta Roos,Joel N. Hirschhorn,Göran Berglund,Bo Hedblad,Leif Groop,David Altshuler,Christopher Newton-Cheh,Marju Orho-Melander +12 more
TL;DR: A genotype score of nine validated SNPs that are associated with modulation in levels of LDL or HDL cholesterol was an independent risk factor for incident cardiovascular disease.
Journal ArticleDOI
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
Steven A. McCarroll,Alan Huett,Petric Kuballa,Shannon D Chilewski,Aimee Landry,Philippe Goyette,Michael C. Zody,Michael C. Zody,Jennifer L. Hall,Steven R. Brant,Judy H. Cho,Richard H. Duerr,Mark S. Silverberg,Kent D. Taylor,John D. Rioux,John D. Rioux,David Altshuler,David Altshuler,Mark J. Daly,Mark J. Daly,Ramnik J. Xavier +20 more
TL;DR: The results suggest that the CD association at IRGM arises from an alteration in IRGM regulation that affects the efficacy of autophagy and a common deletion polymorphism is identified as a likely causal variant.
Journal ArticleDOI
Multiple regions within 8q24 independently affect risk for prostate cancer.
Christopher A. Haiman,Nick Patterson,Matthew L. Freedman,Matthew L. Freedman,Simon Myers,Malcolm C. Pike,Alicja Waliszewska,Alicja Waliszewska,Alicja Waliszewska,Julie Neubauer,Julie Neubauer,Arti Tandon,Arti Tandon,Christine Schirmer,Christine Schirmer,Gavin J. McDonald,Gavin J. McDonald,Steven C. Greenway,Daniel O. Stram,Loic Le Marchand,Laurence N. Kolonel,Melissa A. Frasco,David T.W. Wong,Loreall Pooler,Kristin G. Ardlie,Ingrid Oakley-Girvan,Alice S. Whittemore,Kathleen A. Cooney,Esther M. John,Sue A. Ingles,David Altshuler,Brian E. Henderson,David Reich,David Reich +33 more
TL;DR: Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined.
Journal ArticleDOI
Calibrating a coalescent simulation of human genome sequence variation
TL;DR: The first calibrated population genetic model is presented and it is shown that, while still arbitrary, it successfully generates simulated data that closely resemble empirical data in allele frequency, linkage disequilibrium, and population differentiation.
Journal ArticleDOI
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Valeriya Lyssenko,Cecilia Nagorny,Michael R. Erdos,Nils Wierup,Anna Jonsson,Peter Spégel,Marco Bugliani,Richa Saxena,Richa Saxena,Malin Fex,Nicolo Pulizzi,Bo Isomaa,Tiinamaija Tuomi,Peter M. Nilsson,Johanna Kuusisto,Jaakko Tuomilehto,Michael Boehnke,David Altshuler,David Altshuler,Frank Sundler,Johan G. Eriksson,Anne U. Jackson,Markku Laakso,Piero Marchetti,Richard M. Watanabe,Hindrik Mulder,Leif Groop,Leif Groop +27 more
TL;DR: In this paper, the authors showed that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies, and the risk was associated with impairment of early insulin response to both oral and intravenous glucose and with faster deterioration of insulin secretion over time.