D
David Altshuler
Researcher at University of Michigan
Publications - 353
Citations - 226195
David Altshuler is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 162, co-authored 345 publications receiving 201782 citations. Previous affiliations of David Altshuler include Vertex Pharmaceuticals & Massachusetts Institute of Technology.
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Journal ArticleDOI
Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region
Jose C. Florez,Noël P. Burtt,Paul I.W. de Bakker,Peter Almgren,Tiinamaija Tuomi,Johan Holmkvist,Daniel Gaudet,Thomas J. Hudson,Steve F. Schaffner,Mark J. Daly,Joel N. Hirschhorn,Leif Groop,David Altshuler +12 more
TL;DR: It is shown that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
Journal ArticleDOI
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
Kelan G. Tantisira,Stephen L. Lake,Eric S. Silverman,Lyle J. Palmer,Ross Lazarus,Edwin K. Silverman,Stephen B. Liggett,Erwin W. Gelfand,Lanny J. Rosenwasser,Brent Richter,Elliot Israel,Michael E. Wechsler,Stacey Gabriel,David Altshuler,Eric S. Lander,Jeffrey M. Drazen,Scott T. Weiss +16 more
TL;DR: Variation in one gene, corticotropin-releasing hormone receptor 1 (CRHR1) was consistently associated with enhanced response to therapy in each of the three populations utilizing inhaled corticosteroids as the primary therapy in at least one treatment arm, and suggests this gene pathway as a potential novel therapeutic target.
Journal ArticleDOI
Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Christopher J. O'Donnell,Christopher J. O'Donnell,Maryam Kavousi,Albert V. Smith,Sharon L.R. Kardia,Sharon L.R. Kardia,Mary F. Feitosa,Shih-Jen Hwang,Yan V. Sun,Michael A. Province,Thor Aspelund,Abbas Dehghan,Udo Hoffmann,Lawrence F. Bielak,Qunyuan Zhang,Gudny Eiriksdottir,Cornelia M. van Duijn,Caroline S. Fox,Caroline S. Fox,Mariza de Andrade,Aldi T. Kraja,Sigurdur Sigurdsson,Suzette E. Elias-Smale,Joanne M. Murabito,Lenore J. Launer,Aad van der Lugt,Sekar Kathiresan,Gabriel P. Krestin,David M. Herrington,Timothy D. Howard,Yongmei Liu,Wendy S. Post,Braxton D. Mitchell,Jeffrey R. O'Connell,Haiqing Shen,Alan R. Shuldiner,David Altshuler,David Altshuler,Roberto Elosua,Veikko Salomaa,Stephen M. Schwartz,David S. Siscovick,Benjamin F. Voight,Benjamin F. Voight,Joshua C. Bis,Nicole L. Glazer,Bruce M. Psaty,Eric Boerwinkle,Gerardo Heiss,Stefan Blankenberg,Tanja Zeller,Philipp S. Wild,Renate B. Schnabel,Arne Schillert,Andreas Ziegler,Thomas Münzel,Charles C. White,Jerome I. Rotter,Mike A. Nalls,Matthijs Oudkerk,Andrew D. Johnson,Anne B. Newman,André G. Uitterlinden,Joseph M. Massaro,Julie M. Cunningham,Tamara B. Harris,Albert Hofman,Patricia A. Peyser,Ingrid B. Borecki,L. Adrienne Cupples,Vilmundur Gudnason,Jacqueline C.M. Witteman +71 more
TL;DR: SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there is suggestive associations with both Cac and MI of SNPs in additional loci.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena,Richa Saxena,Clara C. Elbers,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Archana Tare,Berta Almoguera Castillo,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten,Robert A. Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +163 more
TL;DR: Large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to type 2 diabetes risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.
Journal ArticleDOI
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
Marju Orho-Melander,Olle Melander,Candace Guiducci,Pablo Perez-Martinez,Pablo Perez-Martinez,Dolores Corella,Charlotta Roos,Ryan Tewhey,Mark J. Rieder,Jennifer L. Hall,Gonçalo R. Abecasis,E. Shyong Tai,Cullan Welch,Donna K. Arnett,Valeriya Lyssenko,Eero Lindholm,Richa Saxena,Paul I.W. de Bakker,Noël P. Burtt,Benjamin F. Voight,Joel N. Hirschhorn,Katherine L. Tucker,Thomas Hedner,Tiinamaija Tuomi,Bo Isomaa,Karl-Fredrik Eriksson,Marja-Riitta Taskinen,Björn Wahlstrand,Thomas Edward Hughes,Laurence D. Parnell,Chao-Qiang Lai,Göran Berglund,Leena Peltonen,Erkki Vartiainen,Pekka Jousilahti,Aki S. Havulinna,Veikko Salomaa,Peter M. Nilsson,Leif Groop,Leif Groop,David Altshuler,Jose M. Ordovas,Sekar Kathiresan +42 more
TL;DR: These findings point to a molecular mechanism in humans by which higher triglycerides and CRP can be coupled with lower plasma glucose concentrations and position GCKR in central pathways regulating both hepatic triglyceride and glucose metabolism.