Debbie A Lawlor

TL;DR: There is no evidence of an effect of exposure to low levels of iron in pregnancy on offspring cognition at age 8, and strong associations between HFE and TMPRSS6 genotypes and mother’s haemoglobin levels early in pregnancy are found.

TL;DR: The results suggest that some parental preconceptual characteristics and environmental exposures while the child is in utero may influence the long-term ovarian development and function in female offspring.

TL;DR: Most metabolic traits had high rank correlation and minimal differences in mean concentrations between samples subjected to reference and the different conditions tested, that may commonly occur in studies, however, glycolysis metabolites, histidine, acetate and diacylglycerol concentrations may be compromised and this could bias results in association/causal analyses.

TL;DR: The findings suggest that HDP is strongly and independently associated with future hypertension, and women who experience this condition should be counselled regarding lifestyle modification and careful ongoing blood pressure monitoring, however, the development of HDP during pregnancy does not improve the capacity to predict future hypertension.

TL;DR: The findings suggest that theory driven interventions, like AFLY5, can fail to influence most potential mediators and this may explain the failure of the intervention to improve most primary and secondary outcomes.