D
Debbie A Lawlor
Researcher at University of Bristol
Publications - 1118
Citations - 118183
Debbie A Lawlor is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Body mass index. The author has an hindex of 147, co-authored 1114 publications receiving 101123 citations. Previous affiliations of Debbie A Lawlor include Southampton General Hospital & University of Vermont.
Papers
More filters
Posted ContentDOI
Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.
Álvaro Hernáez,Álvaro Hernáez,Álvaro Hernáez,Tormod Rogne,Tormod Rogne,Karoline H Skåra,Siri E. Håberg,Christian M. Page,Christian M. Page,Abigail Fraser,Stephen Burgess,Debbie A Lawlor,Maria C. Magnus,Maria C. Magnus +13 more
TL;DR: In this paper, the authors investigated the relationship between BMI and subfertility in both sexes, when using both a standard multivariable regression and a Mendelian randomization analysis, further supporting a potential causal role of BMI on sub-fertility.
Posted ContentDOI
Sex-specific trajectories of molecular cardiometabolic trait concentrations through childhood, adolescence and young adulthood: a cohort study
Linda M. O’Keeffe,Linda M. O’Keeffe,Kate Tilling,Joshua A. Bell,Matthew Lee,Debbie A Lawlor,George Davey Smith,Patricia M. Kearney +7 more
Abstract: Background: Causal risk factors and predictive biomarkers for cardiometabolic diseases are increasingly being identified from comprehensive metabolomic profiling in epidemiological studies. The changes which typically occur in molecular cardiometabolic traits across early life are not well characterised.
Methods: We quantified sex-specific trajectories of 148 metabolic trait concentrations including various lipoprotein subclasses from age 7y to 25y. Data were from offspring of the Avon Longitudinal Study of Parents and Children birth cohort study. Outcomes included concentrations of 148 traits quantified using nuclear magnetic resonance spectroscopy measured at 7y, 15y, 18y and 25y. Sex-specific trajectories of each trait concentration were modelled using linear spline multilevel models with robust standard errors.
Findings: 7,065-7,626 participants (11,702-14,797 repeated measures) were included in analyses. Females had higher very-low-density lipoprotein (VLDL) particle concentrations at 7y. VLDL particle concentrations decreased from 7y to 25y with larger decreases in females, leading to lower VLDL particle concentrations at 25y in females. For example, females had 0.25 SD (95% Confidence Interval (CI), 0.20, 0.31) higher very small VLDL particle concentration at 7y; mean levels decreased by 0.06 SDs (95% CI, -0.01, 0.13) in males and 0.85 SDs (95% CI, 0.79, 0.90) in females from 7y to 25y leading to 0.42 SD (95% CI, 0.35, 0.48) lower very small VLDL particle concentrations in females at 25y. Females also had higher low-density lipoprotein (LDL) particle concentrations at 7y; these increased from 7y to 25y in both sexes and increases were larger among males. By age 25y, LDL particle concentrations remained higher in females but the sex difference was smaller than in early childhood. Females had lower high-density lipoprotein (HDL) particle concentrations at 7y. HDL particle concentrations increased from 7y to 25y with larger increases among females leading to higher HDL particle concentrations in females at 25y.
Interpretation: Childhood and adolescence are important periods for the emergence of sex differences in atherogenic lipids and predictive biomarkers for cardiometabolic disease, mostly to the detriment of males.
Journal ArticleDOI
Cohort profile: a national, population-based cohort of children born after assisted conception in the UK (1992-2009): methodology and birthweight analysis.
Mitana Purkayastha,Stephen A Roberts,Julian Gardiner,Daniel R. Brison,Scott M. Nelson,Debbie A Lawlor,Barbara Luke,Alastair G. Sutcliffe +7 more
TL;DR: In this article, the effects of fresh and frozen embryo transfer on birth weight were analysed to test the validity of the cohort and to explore the relationship between ART conception and short-term and long-term health outcomes in offspring.
Posted ContentDOI
Associations of insomnia on pregnancy and perinatal outcomes: Findings from Mendelian randomization and conventional observational studies in up to 356,069 women
Qian Yang,M. Carolina Borges,Eleanor Sanderson,Maria C. Magnus,Maria C. Magnus,Fanny Kilpi,Paul J. Collings,Ana Luiza Gonçalves Soares,Jane West,Per Magnus,John Wright,Siri E. Håberg,Kate Tilling,Kate Tilling,Debbie A Lawlor,Debbie A Lawlor +15 more
TL;DR: In this article, Mendelian randomization was used to test whether insomnia causes stillbirth, miscarriage, gestational diabetes, hypertensive disorders of pregnancy, perinatal depression, preterm birth, or low/high offspring birthweight (LBW/HBW).
Posted ContentDOI
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration
Xueping Liu,Dorte Helenius,Dorte Helenius,Line Skotte,Robin N Beaumont,Matthias Wielscher,Frank Geller,Julius Juodakis,Anubha Mahajan,Jonathan P. Bradfield,Frederick T.J. Lin,Suzanne Vogelezang,Mariona Bustamante,Tarunveer S. Ahluwalia,Niina Pitkänen,Carol A. Wang,Jonas Bacelis,Maria Carolina Borges,Ge Zhang,Ge Zhang,Bruce Bedell,Robert M. Rossi,Robert M. Rossi,Kristin Skogstrand,Kristin Skogstrand,Shouneng Peng,Wesley K. Thompson,Wesley K. Thompson,Vivek Appadurai,Vivek Appadurai,Debbie A Lawlor,Ilkka Kalliala,Ilkka Kalliala,Christine Power,Mark I. McCarthy,Mark I. McCarthy,Heather A. Boyd,Mary L. Marazita,Hakon Hakonarson,Hakon Hakonarson,M. Geoffrey Hayes,Denise M. Scholtens,Fernando Rivadeneira,Vincent W. V. Jaddoe,Rebecca K. Vinding,Hans Bisgaard,Bridget A. Knight,Katja Pahkala,Olli T. Raitakari,Olli T. Raitakari,Øyvind Helgeland,Øyvind Helgeland,Øyvind Helgeland,Stefan Johansson,Stefan Johansson,Pål R. Njølstad,Pål R. Njølstad,João Fadista,Andrew J. Schork,Andrew J. Schork,Ron Nudel,Ron Nudel,Daniel Miller,Xiaoting Chen,Matthew T. Weirauch,Matthew T. Weirauch,Preben Bo Mortensen,Preben Bo Mortensen,Anders D. Børglum,Anders D. Børglum,Merete Nordentoft,Merete Nordentoft,Merete Nordentoft,Ole Mors,Ole Mors,Ke Hao,Kelli K. Ryckman,David M. Hougaard,David M. Hougaard,Leah C. Kottyan,Leah C. Kottyan,Craig E. Pennell,Leo-Pekka Lyytikäinen,Klaus Bønnelykke,Martine Vrijheid,Janine F. Felix,William L. Lowe,Struan F.A. Grant,Struan F.A. Grant,Elina Hyppönen,Elina Hyppönen,Bo Jacobsson,Bo Jacobsson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Louis J. Muglia,Jeffrey C. Murray,Rachel M. Freathy,Rachel M. Freathy,Thomas Werge,Thomas Werge,Thomas Werge,Mads Melbye,Mads Melbye,Alfonso Buil,Alfonso Buil,Bjarke Feenstra +106 more
TL;DR: A fetal genome-wide association meta-analysis of gestational duration, and early preterm, pre term, and postterm birth in 84,689 infants found one locus on chromosome 2q13 was associated with gestationalduration; the association was replicated in 9,291 additional infants (combined P = 3.96 × 10−14).