D
Debbie A Lawlor
Researcher at University of Bristol
Publications - 1118
Citations - 118183
Debbie A Lawlor is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Body mass index. The author has an hindex of 147, co-authored 1114 publications receiving 101123 citations. Previous affiliations of Debbie A Lawlor include Southampton General Hospital & University of Vermont.
Papers
More filters
Journal ArticleDOI
A genome-wide association study of body mass index across early life and childhood
Nicole M. Warrington,Laura D Howe,Lavinia Paternoster,Marika Kaakinen,Sauli Herrala,Ville Huikari,Y. Wu,John P. Kemp,Nicholas J. Timpson,Beate St Pourcain,George Davey Smith,Kate Tilling,Marjo-Riitta Järvelin,Craig E. Pennell,David M. Evans,Debbie A Lawlor,Laurent Briollais,Lyle J. Palmer +17 more
TL;DR: This genome-wide association study of BMI trajectories over childhood identified a novel locus that warrants further investigation and demonstrated that the use of repeated measures data can increase power to allow detection of genetic loci with smaller sample sizes.
Journal ArticleDOI
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index
Rachel M. Freathy,Gbenga Kazeem,Richard W Morris,Paul C. D. Johnson,Lavinia Paternoster,Shah Ebrahim,Andrew T. Hattersley,Anita Hill,Aroon D. Hingorani,Claus Holst,Barbara J. Jefferis,Sofia I. Iqbal Kring,Vincent Mooser,Sandosh Padmanabhan,Martin Preisig,Susan M. Ring,Naveed Sattar,Mark N. Upton,Peter Vollenweider,Gérard Waeber,Thorkild I. A. Sørensen,Timothy M. Frayling,Graham Watt,Debbie A Lawlor,Peter H. Whincup,Federica Tozzi,George Davey Smith,Marcus R. Munafò +27 more
TL;DR: Smoking status modifies the association between the 15q25 SNP, rs1051730, and BMI, which strengthens evidence that smoking exposure is causally associated with reduced BMI.
Journal ArticleDOI
Childhood obesity and vascular phenotypes: a population study.
Marietta Charakida,Alexander Jones,Emanuela Falaschetti,Tauseef Khan,Nick Finer,Naveed Sattar,Aroon D. Hingorani,Debbie A Lawlor,George Davey Smith,John E. Deanfield +9 more
TL;DR: Greater childhood adiposity is associated with adverse cardiometabolic risk factors, but with no evidence of vascular damage at age 9 to 11 years, which could represent physiological adaptation to the hyperemic state of adiposity in childhood.
Journal ArticleDOI
Social inequalities in antidepressant treatment and mortality: a longitudinal register study
Mika Kivimäki,David Gunnell,Debbie A Lawlor,George Davey Smith,Jaana Pentti,Marianna Virtanen,Marko Elovainio,Timo Klaukka,Jussi Vahtera +8 more
TL;DR: A mismatch in the treatment of depression relative to apparent clinical need is suggested, with the lowest levels of treatment concentrated in the lower socio-economic groups, despite evidence of their increased prevalence of depression and suicide.
Journal ArticleDOI
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.
Jon White,Reecha Sofat,Gibran Hemani,Tina Shah,Jorgen Engmann,Caroline Dale,Sonia Shah,Felix A. Kruger,Claudia Giambartolomei,Daniel I. Swerdlow,Tom Palmer,Stela McLachlan,Claudia Langenberg,Claudia Langenberg,Delilah Zabaneh,Ruth C. Lovering,Alana Cavadino,Barbara J. Jefferis,Chris Finan,Andrew Wong,Antoinette Amuzu,Ken K. Ong,Tom R. Gaunt,Helen R. Warren,Teri Louise Davies,Fotios Drenos,Fotios Drenos,Jackie A. Cooper,Shah Ebrahim,Debbie A Lawlor,Philippa J. Talmud,Steve E. Humphries,Christine Power,Elina Hyppönen,Elina Hyppönen,Marcus Richards,Rebecca Hardy,Diana Kuh,Nicholas J. Wareham,Yoav Ben-Shlomo,Ian N. M. Day,Peter H. Whincup,Richard W Morris,Mark W. J. Strachan,Jacqueline F. Price,Meena Kumari,Mika Kivimäki,Vincent Plagnol,John C. Whittaker,George Davey Smith,Frank Dudbridge,Juan P. Casas,Juan P. Casas,Michael V. Holmes,Michael V. Holmes,Aroon D. Hingorani +55 more
TL;DR: Conventional and multivariate Mendelian randomisation analysis implicates a causal role for urate in the development of coronary heart disease, but these estimates might be inflated by hidden pleiotropy.