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Debbie A Lawlor
Researcher at University of Bristol
Publications - 1118
Citations - 118183
Debbie A Lawlor is an academic researcher from University of Bristol. The author has contributed to research in topics: Population & Body mass index. The author has an hindex of 147, co-authored 1114 publications receiving 101123 citations. Previous affiliations of Debbie A Lawlor include Southampton General Hospital & University of Vermont.
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Journal ArticleDOI
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome
Felix R. Day,David A. Hinds,Joyce Y. Tung,Lisette Stolk,Unnur Styrkarsdottir,Richa Saxena,Andrew Bjonnes,Linda Broer,David B. Dunger,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Debbie A Lawlor,Guillaume Laval,Iain Mathieson,Wendy L. McCardle,Yvonne V. Louwers,Cindy Meun,Susan M. Ring,Robert A. Scott,Patrick Sulem,André G. Uitterlinden,Nicholas J. Wareham,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Corrine K. Welt,Kari Stefansson,Kari Stefansson,Joop S.E. Laven,Ken K. Ong,John R. B. Perry +29 more
TL;DR: This large-scale study implicates an aetiological role of the epidermal growth factor receptors, infers causal mechanisms relevant to clinical management and prevention, and suggests balancing selection mechanisms involved in PCOS risk.
Journal ArticleDOI
Socioeconomic inequalities in health
TL;DR: The effects of age and sex may be overlooked in children under the age of 15 and the effects of disease and age-related illnesses are overlooked.
Journal ArticleDOI
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.
Michael V. Holmes,Paul J. Newcombe,Paul J. Newcombe,Jaroslav A. Hubacek,Reecha Sofat,Sally L. Ricketts,Jackie A. Cooper,Monique M.B. Breteler,Leonelo E. Bautista,Pankaj Sharma,John C. Whittaker,John C. Whittaker,Liam Smeeth,F. Gerald R. Fowkes,Ale Algra,Ale Algra,Veronika M. Shmeleva,Zoltan Szolnoki,Mark Roest,Michael Linnebank,Jeppe Zacho,Mike A. Nalls,Andrew B. Singleton,Luigi Ferrucci,John Hardy,Bradford B. Worrall,Stephen S. Rich,Mar Matarin,Paul Norman,Leon Flicker,Osvaldo P. Almeida,Frank M. van Bockxmeer,Hiroshi Shimokata,Kay-Tee Khaw,Nicholas J. Wareham,Martin Bobak,Jonathan A C Sterne,George Davey Smith,Philippa J. Talmud,Cornelia M. van Duijn,Steve E. Humphries,Jackie F. Price,Shah Ebrahim,Debbie A Lawlor,Graeme J. Hankey,James F. Meschia,Manjinder S. Sandhu,Aroon D. Hingorani,Juan P. Casas,Juan P. Casas +49 more
TL;DR: In regions with increasing levels or established policies of population folate supplementation, evidence from genetic studies and randomised trials is concordant in suggesting an absence of benefit from lowering of homocysteine for prevention of stroke.
Journal ArticleDOI
Is the Association Between Parity and Coronary Heart Disease Due to Biological Effects of Pregnancy or Adverse Lifestyle Risk Factors Associated With Child-Rearing? Findings From the British Women’s Heart and Health Study and the British Regional Heart Study
Debbie A Lawlor,Jonathan Emberson,Shah Ebrahim,Peter H. Whincup,S. Goya Wannamethee,Mary Walker,George Davey Smith +6 more
TL;DR: Lifestyle risk factors associated with child-rearing lead to obesity and result in increased CHD in both sexes; biological responses of pregnancy may have additional adverse effects in women.
Journal ArticleDOI
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Lisette Stolk,John R. B. Perry,John R. B. Perry,Daniel I. Chasman,Chunyan He,Massimo Mangino,Patrick Sulem,Maja Barbalić,Linda Broer,Enda M. Byrne,Florian Ernst,Tmu Esko,Nora Franceschini,Daniel F. Gudbjartsson,Jouke-Jan Hottenga,Peter Kraft,Peter Kraft,Patrick F. McArdle,Eleonora Porcu,So-Youn Shin,Albert V. Smith,Sophie H. Van Wingerden,Guangju Zhai,Guangju Zhai,Wei V. Zhuang,Eva Albrecht,Behrooz Z. Alizadeh,Thor Aspelund,Stefania Bandinelli,Lovorka Barać Lauc,Jacques S. Beckmann,Mladen Boban,Eric Boerwinkle,Frank J.M. Broekmans,Andrea Burri,Harry Campbell,Stephen J. Chanock,Constance Chen,Marilyn C. Cornelis,Tanguy Corre,Andrea D. Coviello,Pio D'Adamo,Gail Davies,Ulf de Faire,Eco J. C. de Geus,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Shah Ebrahim,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Bart C.J.M. Fauser,Liana Ferreli,Luigi Ferrucci,Krista Fischer,Aaron R. Folsom,Melissa E. Garcia,Paolo Gasparini,Christian Gieger,Nicole L. Glazer,Diederick E. Grobbee,Per Hall,Toomas Haller,Susan E. Hankinson,Merli Hass,Caroline Hayward,Andrew C. Heath,Albert Hofman,Erik Ingelsson,A. Cecile J.W. Janssens,Andrew D. Johnson,David Karasik,David Karasik,Sharon L.R. Kardia,Jules J. Keyzer,Douglas P. Kiel,Douglas P. Kiel,Ivana Kolcic,Z. Kutalik,Z. Kutalik,Jari Lahti,Sandra Lai,Triin Laisk,Joop S.E. Laven,Debbie A Lawlor,Jianjun Liu,Lorna M. Lopez,Yvonne V. Louwers,Patrik K. E. Magnusson,Mara Marongiu,Nicholas G. Martin,Irena Martinović Klarić,Corrado Masciullo,Barbara McKnight,Sarah E. Medland,David Melzer,Vincent Mooser,Pau Navarro,Anne B. Newman,Dale R. Nyholt,N. Charlotte Onland-Moret,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alexander N. Parker,Nancy L. Pedersen,Petra H.M. Peeters,Giorgio Pistis,Andrew S. Plump,Ozren Polasek,Victor J M Pop,Bruce M. Psaty,Bruce M. Psaty,Katri R Currency Signikkönen,Emil Rehnberg,Jerome I. Rotter,Igor Rudan,Igor Rudan,Cinzia Sala,Andres Salumets,Angelo Scuteri,Andrew B. Singleton,Jennifer A. Smith,Harold Snieder,Nicole Soranzo,Nicole Soranzo,Simon N. Stacey,John M. Starr,Maria G. Stathopoulou,Kathleen Stirrups,Ronald P. Stolk,Unnur Styrkarsdottir,Yan V. Sun,Albert Tenesa,Barbara Thorand,Daniela Toniolo,Laufey Tryggvadottir,Kim Tsui,Sheila Ulivi,Rob M. van Dam,Rob M. van Dam,Yvonne T. van der Schouw,Carla H. van Gils,Peter Van Nierop,Jacqueline M. Vink,Peter M. Visscher,Peter M. Visscher,Marlies Voorhuis,Gérard Waeber,Henri Wallaschofski,H.-Erich Wichmann,Elisabeth Widen,Colette J M Wijnands-van Gent,Gonneke Willemsen,James F. Wilson,Bruce H. R. Wolffenbuttel,Alan F. Wright,Laura M. Yerges-Armstrong,Tatijana Zemunik,Lina Zgaga,Lina Zgaga,M. Carola Zillikens,Marek Zygmunt,Alice M. Arnold,Dorret I. Boomsma,Julie E. Buring,Laura Crisponi,Ellen W. Demerath,Ellen W. Demerath,Vilmundur Gudnason,Tamara B. Harris,Frank B. Hu,David J. Hunter,David J. Hunter,Lenore J. Launer,Andres Metspalu,Grant W. Montgomery,Ben A. Oostra,Paul M. Ridker,Serena Sanna,David Schlessinger,Tim D. Spector,Kari Stefansson,Kari Stefansson,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Manuela Uda,André G. Uitterlinden,Cornelia M. van Duijn,Henry Völzke,Anna Murray,Anna Murray,Joanne M. Murabito,Jenny A. Visser,Jenny A. Visser,Kathryn L. Lunetta,Kathryn L. Lunetta +198 more
TL;DR: A meta-analysis of 22 genome-wide association studies in 38,968 women of European descent identified 13 loci newly associated with age at natural menopause, including genes implicated in DNA repair, immune function and immune function.