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Stephen H. Settle
Researcher at Vanderbilt University
Publications - 8
Citations - 1195
Stephen H. Settle is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Regulation of gene expression & Ménétrier's disease. The author has an hindex of 7, co-authored 8 publications receiving 1135 citations. Previous affiliations of Stephen H. Settle include United States Department of Veterans Affairs.
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Journal ArticleDOI
The nature and identification of quantitative trait loci: a community's view.
Oduola Abiola,Joe M. Angel,Philip Avner,Alexander A. Bachmanov,John K. Belknap,Beth Bennett,Elizabeth P. Blankenhorn,David A. Blizard,Valerie J. Bolivar,Gudrun A. Brockmann,Kari J. Buck,Jean Francois Bureau,William L. Casley,Elissa J. Chesler,James M. Cheverud,Gary A. Churchill,Melloni N. Cook,John C. Crabbe,Wim E. Crusio,Ariel Darvasi,Gerald de Haan,Peter Demant,Rebecca W. Doerge,Rosemary W. Elliott,Charles R. Farber,Lorraine Flaherty,Jonathan Flint,Howard K. Gershenfeld,John P. Gibson,Jing Gu,Weikuan Gu,Heinz Himmelbauer,Robert Hitzemann,Hui-Chen Hsu,Kent W. Hunter,Fuad A. Iraqi,Ritsert C. Jansen,Thomas E. Johnson,Byron C. Jones,Gerd Kempermann,Frank Lammert,Lu Lu,Kenneth F. Manly,Douglas B. Matthews,Juan F. Medrano,Margarete Mehrabian,Guy Mittleman,Beverly A. Mock,Jeffrey S. Mogil,Xavier Montagutelli,Grant Morahan,John D. Mountz,Hiroki Nagase,Richard S. Nowakowski,Bruce F. O'Hara,Alexander V. Osadchuk,Beverly Paigen,Abraham A. Palmer,Jeremy L. Peirce,Daniel Pomp,Michael Rosemann,Glenn D. Rosen,Leonard C. Schalkwyk,Ze'ev Seltzer,Stephen H. Settle,Kazuhiro Shimomura,Siming Shou,James M. Sikela,Linda D. Siracusa,Jimmy L. Spearow,Cory Teuscher,David W. Threadgill,Linda A. Toth,A. A. Toye,Csaba Vadasz,Gary Van Zant,Edward K. Wakeland,Robert W. Williams,Huang-Ge Zhang,Fei Zou +79 more
TL;DR: This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits.
Journal ArticleDOI
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
Sergio Kaiser,Young-Kyu Park,Jeffrey L. Franklin,Richard B. Halberg,Ming Yu,Walter J. Jessen,Johannes M. Freudenberg,Xiaodi Chen,Kevin M. Haigis,Anil G. Jegga,Sue Kong,Bhuvaneswari Sakthivel,Huan Xu,Timothy Reichling,Mohammad Azhar,Gregory P. Boivin,Reade B. Roberts,Anika C. Bissahoyo,Fausto Gonzales,Greg Bloom,Steven A. Eschrich,Scott L. Carter,Jeremy Aronow,John Kleimeyer,Michael Kleimeyer,Vivek Ramaswamy,Stephen H. Settle,Braden Boone,Shawn Levy,Jonathan M. Graff,Thomas Doetschman,Joanna Groden,William F. Dove,David W. Threadgill,Timothy J. Yeatman,Robert J. Coffey,Bruce J. Aronow +36 more
TL;DR: Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis and provide a general method for identifying pattern-specific biomarkers and therapeutic targets.
Journal ArticleDOI
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
Reade B. Roberts,Lu Min,M. Kay Washington,Sandra J. Olsen,Stephen H. Settle,Robert J. Coffey,Robert J. Coffey,David W. Threadgill,David W. Threadgill +8 more
TL;DR: It is suggested that normal Egfr activity is required for establishment of intestinal tumors in the ApcMin model between initiation and subsequent expansion of initiated tumors, suggesting that Egfr inhibitors may be useful for advanced colorectal cancer treatment.
Journal ArticleDOI
Evidence for Repatterning of the Gastric Fundic Epithelium Associated With Ménétrier’s Disease and TGFα Overexpression
Sachiyo Nomura,Sachiyo Nomura,Stephen H. Settle,Charles M. Leys,Anna L. Means,Richard M. Peek,Richard M. Peek,Steven D. Leach,Christopher V.E. Wright,Robert J. Coffey,Robert J. Coffey,James R. Goldenring,James R. Goldenring +12 more
TL;DR: Overexpression of TGFalpha in MT-TGFalpha mice and Ménétrier's disease patients elicits ectopic expression in the fundus of Pdx1, consistent with the phenotype of antralization.
Journal ArticleDOI
The silver gene of Drosophila melanogaster encodes multiple carboxypeptidases similar to mammalian prohormone-processing enzymes.
TL;DR: The identified and cloned the DNA encoding the svr gene and the sequence of several partially overlapping cDNAs derived from svr mRNAs indicates that the silver proteins are members of the family of preprotein-processing carboxypeptidases that includes the human carboxypes E, M, and N.