J
James M. Sikela
Researcher at University of Colorado Denver
Publications - 107
Citations - 9281
James M. Sikela is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Gene & DUF1220. The author has an hindex of 43, co-authored 106 publications receiving 8897 citations. Previous affiliations of James M. Sikela include University of Colorado Hospital & Anschutz Medical Campus.
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Journal ArticleDOI
Evolutionary and biomedical insights from the rhesus macaque genome
Richard A. Gibbs,Jeffrey Rogers,Michael G. Katze,Roger E. Bumgarner,George M. Weinstock,Elaine R. Mardis,Karin A. Remington,Robert L. Strausberg,J. Craig Venter,Richard K. Wilson,Mark A. Batzer,Carlos Bustamante,Evan E. Eichler,Matthew W. Hahn,Ross C. Hardison,Kateryna D. Makova,Webb Miller,Aleksandar Milosavljevic,Robert E. Palermo,Adam Siepel,James M. Sikela,Tony Attaway,Stephanie Bell,Kelly E. Bernard,Christian J. Buhay,Mimi N. Chandrabose,Marvin Diep Dao,Clay Davis,Kimberly D. Delehaunty,Yan Ding,Huyen Dinh,Shannon Dugan-Rocha,Lucinda Fulton,Ramatu Ayiesha Gabisi,Toni T. Garner,Jennifer Godfrey,Alicia Hawes,Judith Hernandez,Sandra Hines,Michael Holder,Jennifer Hume,Shalini N. Jhangiani,Vandita Joshi,Ziad Khan,Ewen F. Kirkness,Andrew Cree,R. Gerald Fowler,Sandra L. Lee,Lora Lewis,Zhangwan Li,Yih-shin Liu,Stephanie M. Moore,Donna M. Muzny,Lynne V. Nazareth,Dinh Ngoc Ngo,Geoffrey Okwuonu,Grace Pai,David A. Parker,Heidie A. Paul,Cynthia Pfannkoch,Craig Pohl,Yu-Hui Rogers,San Juana Ruiz,Aniko Sabo,Jireh Santibanez,Brian W. Schneider,Scott M. Smith,Erica Sodergren,Amanda F. Svatek,Teresa Utterback,Selina Vattathil,Wesley C. Warren,Courtney Sherell White,Asif T. Chinwalla,Yucheng Feng,Aaron L. Halpern,LaDeana W. Hillier,Xiaoqiu Huang,Patrick Minx,Joanne O. Nelson,Kymberlie H. Pepin,Xiang Qin,Granger G. Sutton,Eli Venter,Brian P. Walenz,John W. Wallis,Kim C. Worley,Shiaw-Pyng Yang,Steven J. M. Jones,Marco A. Marra,Mariano Rocchi,Jacqueline E. Schein,Robert Baertsch,Laura Clarke,Miklós Csürös,Jarret Glasscock,R. Alan Harris,Paul Havlak,Andrew R. Jackson,Huaiyang Jiang,Yue Liu,David N. Messina,Yufeng Shen,Henry Xing-Zhi Song,Todd Wylie,Lan Zhang,Ewan Birney,Kyudong Han,Miriam K. Konkel,Jungnam Lee,Arian F.A. Smit,Brygg Ullmer,Hui Wang,Jinchuan Xing,Jinchuan Xing,Richard Burhans,Ze Cheng,John E. Karro,Jian Ma,Brian J. Raney,Xinwei She,Michael J. Cox,Jeffery P. Demuth,Laura J. Dumas,Sang-Gook Han,Janet A. Hopkins,Anis Karimpour-Fard,Young Ho Kim,Jonathan R. Pollack,Tomas Vinar,Charles Addo-Quaye,Jeremiah D. Degenhardt,Alexandra Denby,Melissa J. Hubisz,Amit Indap,Carolin Kosiol,Bruce T. Lahn,Heather A. Lawson,Alison Marklein,Rasmus Nielsen,Eric J. Vallender,Andrew G. Clark,Betsy Ferguson,Ryan D. Hernandez,Kashif Hirani,Hildegard Kehrer-Sawatzki,Jessica Kolb,Shobha Patil,Ling-Ling Pu,Yanru Ren,David Glenn Smith,David A. Wheeler,Ian Schenck,Edward V. Ball,Rui Chen,David Neil Cooper,Belinda Giardine,Fan Hsu,W. James Kent,Arthur M. Lesk,David L. Nelson,William E. O'Brien,Kay Prüfer,Peter D. Stenson,James C. Wallace,Hui Ke,Xiaoming Liu,Peng Wang,Andy Peng Xiang,Fan Yang,Galt P. Barber,David Haussler,David Haussler,Donna Karolchik,Andrew D. Kern,Robert M. Kuhn,Kayla E. Smith,Ann S. Zwieg +177 more
TL;DR: The genome sequence of an Indian-origin Macaca mulatta female is determined and compared with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families.
Journal ArticleDOI
A gene map of the human genome
Gregory D. Schuler,Mark S. Boguski,Elizabeth A. Stewart,Lincoln Stein,Gabor Gyapay,Kate Rice,Robert E. White,P. Rodriguez-Tomé,Amita Aggarwal,Eva Bajorek,S. Bentolila,B. B. Birren,Adam Butler,Andrew B. Castle,N. Chiannilkulchai,Angela M. Chu,C M Clee,Sid Cowles,P. J. R. Day,T. Dibling,N. Drouot,Ian Dunham,Simone Duprat,C. East,C A Edwards,Jun Fan,Nicole Y. Fang,Cécile Fizames,Christine Garrett,L. Green,David Hadley,Midori A. Harris,Paul Harrison,Shannon T. Brady,Andrew A. Hicks,E. Holloway,L. Hui,S. Hussain,C. Louis-Dit-Sully,J. Ma,A. MacGilvery,Christopher Mader,A. Maratukulam,Tara C. Matise,K. B. McKusick,Jean Morissette,Andrew J. Mungall,Delphine Muselet,H. C. Nusbaum,David C. Page,Ammon B. Peck,Shanti M. Perkins,Mark Piercy,Fawn Qin,John Quackenbush,S A Ranby,Tim Reif,Steve Rozen,C. Sanders,X. She,James Silva,Donna K. Slonim,Carol Soderlund,W.-L. Sun,P. Tabar,T. Thangarajah,Nathalie Vega-Czarny,Douglas Vollrath,S. Voyticky,T. E. Wilmer,Xiao-Yu Wu,Mark Raymond Adams,Charles Auffray,Nicole A.R. Walter,Rhonda Brandon,Anindya Dehejia,Peter N. Goodfellow,R. Houlgatte,James R. Hudson,Susan E. Ide,K. R. Iorio,Wha‐Young Lee,N. Seki,Takahiro Nagase,K. Ishikawa,N. Nomura,Cheryl Phillips,Mihael H. Polymeropoulos,Mina Sandusky,Karin Schmitt,Richard Berry,K. Swanson,R. Torres,J. C. Venter,James M. Sikela,Jacques S. Beckmann,Jean Weissenbach,Richard M. Myers,David R. Cox,Michael R. James,David Bentley,Panos Deloukas,Eric S. Lander,Thomas J. Hudson,Thomas J. Hudson +104 more
TL;DR: The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease.
Journal ArticleDOI
A Physical Map of 30,000 Human Genes
Panos Deloukas,Gregory D. Schuler,G. Gyapay,E. M. Beasley,Carol Soderlund,P. Rodriguez-Tomé,L. Hui,Tara C. Matise,K. B. McKusick,Jacques S. Beckmann,S. Bentolila,M.-T. Bihoreau,B. B. Birren,J. Browne,Adam Butler,A. B. Castle,N. Chiannilkulchai,C. Clee,P. J. R. Day,Anindya Dehejia,T. Dibling,N. Drouot,S. Duprat,C. Fizames,Sidney W. Fox,S. Gelling,L. Green,Paul Harrison,R. Hocking,E. Holloway,Sarah E. Hunt,S. Keil,Philip Lijnzaad,C. Louis-Dit-Sully,Jianpeng Ma,A. Mendis,J.H. Miller,J. Morissette,D. Muselet,H. C. Nusbaum,A. Peck,Steve Rozen,D. Simon,Donna K. Slonim,R. Staples,L. D. Stein,E. A. Stewart,Marc A. Suchard,T. Thangarajah,N. Vega-Czarny,Caleb Webber,Xufeng S. Wu,James R. Hudson,Charles Auffray,N. Nomura,James M. Sikela,Mihael H. Polymeropoulos,M. R. James,Eric S. Lander,Thomas J. Hudson,Richard M. Myers,D. R. Cox,Jean Weissenbach,Mark S. Boguski,D. R. Bentley +64 more
TL;DR: A map of 30,181 human gene-based markers was assembled and integrated with the current genetic map by radiation hybrid mapping, which contains nearly twice as many genes as the previous release and is twofold to threefold more accurate than the previous version.
Journal ArticleDOI
The nature and identification of quantitative trait loci: a community's view.
Oduola Abiola,Joe M. Angel,Philip Avner,Alexander A. Bachmanov,John K. Belknap,Beth Bennett,Elizabeth P. Blankenhorn,David A. Blizard,Valerie J. Bolivar,Gudrun A. Brockmann,Kari J. Buck,Jean Francois Bureau,William L. Casley,Elissa J. Chesler,James M. Cheverud,Gary A. Churchill,Melloni N. Cook,John C. Crabbe,Wim E. Crusio,Ariel Darvasi,Gerald de Haan,Peter Demant,Rebecca W. Doerge,Rosemary W. Elliott,Charles R. Farber,Lorraine Flaherty,Jonathan Flint,Howard K. Gershenfeld,John P. Gibson,Jing Gu,Weikuan Gu,Heinz Himmelbauer,Robert Hitzemann,Hui-Chen Hsu,Kent W. Hunter,Fuad A. Iraqi,Ritsert C. Jansen,Thomas E. Johnson,Byron C. Jones,Gerd Kempermann,Frank Lammert,Lu Lu,Kenneth F. Manly,Douglas B. Matthews,Juan F. Medrano,Margarete Mehrabian,Guy Mittleman,Beverly A. Mock,Jeffrey S. Mogil,Xavier Montagutelli,Grant Morahan,John D. Mountz,Hiroki Nagase,Richard S. Nowakowski,Bruce F. O'Hara,Alexander V. Osadchuk,Beverly Paigen,Abraham A. Palmer,Jeremy L. Peirce,Daniel Pomp,Michael Rosemann,Glenn D. Rosen,Leonard C. Schalkwyk,Ze'ev Seltzer,Stephen H. Settle,Kazuhiro Shimomura,Siming Shou,James M. Sikela,Linda D. Siracusa,Jimmy L. Spearow,Cory Teuscher,David W. Threadgill,Linda A. Toth,A. A. Toye,Csaba Vadasz,Gary Van Zant,Edward K. Wakeland,Robert W. Williams,Huang-Ge Zhang,Fei Zou +79 more
TL;DR: This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits.
Journal ArticleDOI
Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit
Keith A. Wafford,Donald M. Burnett,Nancy J. Leidenheimer,David R. Burt,Jia Bei Wang,Paulo Kofuji,Thomas V. Dunwiddie,R. Adron Harris,James M. Sikela +8 more
TL;DR: Expression of brain mRNA or cRNAs in Xenopus oocytes was used to determine what subunits of the GABAA receptor are required for modulation by barbiturates, benzodiazepines, and ethanol.