The nature and identification of quantitative trait loci: a community's view.
Oduola Abiola,Joe M. Angel,Philip Avner,Alexander A. Bachmanov,John K. Belknap,Beth Bennett,Elizabeth P. Blankenhorn,David A. Blizard,Valerie J. Bolivar,Gudrun A. Brockmann,Kari J. Buck,Jean Francois Bureau,William L. Casley,Elissa J. Chesler,James M. Cheverud,Gary A. Churchill,Melloni N. Cook,John C. Crabbe,Wim E. Crusio,Ariel Darvasi,Gerald de Haan,Peter Demant,Rebecca W. Doerge,Rosemary W. Elliott,Charles R. Farber,Lorraine Flaherty,Jonathan Flint,Howard K. Gershenfeld,John P. Gibson,Jing Gu,Weikuan Gu,Heinz Himmelbauer,Robert Hitzemann,Hui-Chen Hsu,Kent W. Hunter,Fuad A. Iraqi,Ritsert C. Jansen,Thomas E. Johnson,Byron C. Jones,Gerd Kempermann,Frank Lammert,Lu Lu,Kenneth F. Manly,Douglas B. Matthews,Juan F. Medrano,Margarete Mehrabian,Guy Mittleman,Beverly A. Mock,Jeffrey S. Mogil,Xavier Montagutelli,Grant Morahan,John D. Mountz,Hiroki Nagase,Richard S. Nowakowski,Bruce F. O'Hara,Alexander V. Osadchuk,Beverly Paigen,Abraham A. Palmer,Jeremy L. Peirce,Daniel Pomp,Michael Rosemann,Glenn D. Rosen,Leonard C. Schalkwyk,Ze'ev Seltzer,Stephen H. Settle,Kazuhiro Shimomura,Siming Shou,James M. Sikela,Linda D. Siracusa,Jimmy L. Spearow,Cory Teuscher,David W. Threadgill,Linda A. Toth,A. A. Toye,Csaba Vadasz,Gary Van Zant,Edward K. Wakeland,Robert W. Williams,Huang-Ge Zhang,Fei Zou +79 more
TLDR
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits.Abstract:
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?read more
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Mixed linear model approach adapted for genome-wide association studies.
Zhiwu Zhang,Elhan S. Ersoz,Chao-Qiang Lai,Rory J. Todhunter,Hemant K. Tiwari,Michael A. Gore,Peter J. Bradbury,Jianming Yu,Donna K. Arnett,Jose M. Ordovas,Edward S. Buckler,Edward S. Buckler +11 more
TL;DR: A compression approach is reported, called 'compressed MLM', that decreases the effective sample size of such datasets by clustering individuals into groups and a complementary approach, 'population parameters previously determined' (P3D), that eliminates the need to re-compute variance components.
Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
Journal ArticleDOI
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Norbert Hubner,Caroline A. Wallace,Heike Zimdahl,Enrico Petretto,Herbert Schulz,Fiona Maciver,Michael Mueller,Oliver Hummel,Jan Monti,Vaclav Zidek,Alena Musilova,Vladimir Kren,Vladimir Kren,Helen C. Causton,Laurence Game,Gabriele Born,Sabine Schmidt,Anita Müller,Stuart A. Cook,Theodore W. Kurtz,John C. Whittaker,Michal Pravenec,Michal Pravenec,Timothy J. Aitman +23 more
TL;DR: This work mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome in the BXH/HXB panel of rat recombinant inbred strains and generated a data set of 73 candidate genes for hypertension that merit testing in human populations.
Journal ArticleDOI
Strategies for mapping and cloning quantitative trait genes in rodents
TL;DR: New resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin–Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable.
Journal ArticleDOI
Mouse Behavioral Assays Relevant to the Symptoms of Autism
TL;DR: An ideal mouse models will incorporate analogies to the three diagnostic symptoms of autism: abnormal social interactions, deficits in communication and high levels of repetitive behaviors, which will define robust phenotypes in mouse models of autism.
References
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
The sequence of the human genome.
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TL;DR: Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated.
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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Eric S. Lander,Leonid Kruglyak +1 more
TL;DR: Specific standards designed to maintain rigor while also promoting communication are proposed for the interpretation of linkage results in genetic studies under way for many complex traits.
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Sequence the Human Genome
TL;DR: This book aims to provide a history of Chinese modern art from 17th Century to the present day through the lens of 20th Century critics, practitioners, journalists, and mediaeval and modern-day critics.
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Mapping mendelian factors underlying quantitative traits using rflp linkage maps
Eric S. Lander,David Botstein +1 more
TL;DR: In this paper, a set of analytical methods that modify and extend the classical theory for mapping such quantitative trait loci (QTLs) are described, and explicit graphs are provided that allow experimental geneticists to estimate, in any particular case, the number of progeny required to map QTLs underlying a quantitative trait.
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