E
Edson X. Albuquerque
Researcher at University of Maryland, Baltimore
Publications - 268
Citations - 18565
Edson X. Albuquerque is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 69, co-authored 268 publications receiving 17395 citations. Previous affiliations of Edson X. Albuquerque include Federal University of Rio de Janeiro & National Institute on Drug Abuse.
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Journal ArticleDOI
Mammalian nicotinic acetylcholine receptors: from structure to function.
TL;DR: This review provides a comprehensive overview of the advancement of functional and genetic studies in the late 1980s and the more recent revelations of the impact that the rich diversity in function and expression of this receptor family has on neuronal and nonneuronal cells throughout the body.
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NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Polymnia Georgiou,Jonathan Fischell,Greg I. Elmer,Manickavasagom Alkondon,Peixiong Yuan,Heather J. Pribut,Nagendra Singh,Katina Sourou Sylvestre Dossou,Yuhong Fang,Xi Ping Huang,Cheryl L. Mayo,Irving W. Wainer,Edson X. Albuquerque,Scott M. Thompson,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +19 more
TL;DR: It is shown that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice.
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Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Lace M. Riggs,Jaclyn N. Highland,Polymnia Georgiou,Edna F. R. Pereira,Edson X. Albuquerque,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +10 more
TL;DR: Pharmacological target deconvolution of ketamine and its metabolites will provide insight critical to the development of new pharmacotherapies that possess the desirable clinical effects of ketamines, but limit undesirable side effects.
Journal Article
International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits
Ronald J. Lukas,Jean-Pierre Changeux,N. Le Novere,Edson X. Albuquerque,David J.K. Balfour,Darwin K. Berg,D. Bertrand,Vincent A. Chiappinelli,P. B. S. Clarke,Allan C. Collins,J. A. Dani,Sharon R. Grady,Kenneth J. Kellar,Jon Lindstrom,Michael J. Marks,Maryka Quik,Palmer Taylor,Susan Wonnacott +17 more
TL;DR: Nicotinic acetylcholine receptors in jawed vertebrates are prototypical members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic neurotransmitter receptors; see Section IV for selected seminal papers, reviews, and collections).
Journal ArticleDOI
Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons
Manickavasagom Alkondon,Edna F. R. Pereira,Wellington da Silva Côrtes,Wellington da Silva Côrtes,Alfred Maelicke,Edson X. Albuquerque,Edson X. Albuquerque +6 more
TL;DR: The selective action of choline on native α7 nAChRs suggests that this naturally occurring compound may act in vivo as an endogenous ligand for these receptors.