E
Edythe D. London
Researcher at University of California, Los Angeles
Publications - 492
Citations - 36481
Edythe D. London is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nicotinic agonist & Methamphetamine. The author has an hindex of 93, co-authored 482 publications receiving 33741 citations. Previous affiliations of Edythe D. London include Icahn School of Medicine at Mount Sinai & Semel Institute for Neuroscience and Human Behavior.
Papers
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Journal ArticleDOI
Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors
Arthur L. Brody,M. Mandelkern,Edythe D. London,Richard G. Olmstead,Judah Farahi,David Scheibal,Jennifer Jou,Valerie Allen,Emmanuelle Tiongson,Svetlana I. Chefer,Andrei O. Koren,Alexey G. Mukhin +11 more
TL;DR: The extent of receptor occupancy found herein suggests that smoking may lead to withdrawal alleviation by maintaining α4β2* nAChRs in the desensitized state.
Journal ArticleDOI
Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task.
John Monterosso,George Ainslie,Jiansong Xu,Xochitl Cordova,Catherine P. Domier,Edythe D. London +5 more
TL;DR: Apparent inefficiency of cortical processing related to decision‐making in MA abusers may contribute to the neural basis of enhanced delay discounting by this population, but other factors remain to be identified.
Journal ArticleDOI
Smoking-Induced Ventral Striatum Dopamine Release
Arthur L. Brody,Richard G. Olmstead,Edythe D. London,Judah Farahi,Jeffrey H. Meyer,Paul Grossman,Grace S. Lee,Joe Huang,Emily L. Hahn,M. Mandelkern +9 more
TL;DR: It is shown that dopamine release in the ventral striatum underlies the reinforcing properties of nicotine and the magnitude of binding potential changes found was comparable to that found in studies that used similar methods to examine the effects of other addictive drugs.
Journal ArticleDOI
Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain: A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose
Edythe D. London,Nicola G. Cascella,Dean F. Wong,Robert L. Phillips,Robert F. Dannals,Jonathan M. Links,Ronald Herning,Roger F. Grayson,Jerome H. Jaffe,Henry N. Wagner +9 more
TL;DR: Reduced cerebral metabolism is associated with cocaine-induced euphoria and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study.
Journal ArticleDOI
17β-Estradiol Reduces Stroke Injury in Estrogen-Deficient Female Animals
Renata Rusa,Nabil J. Alkayed,Barbara J. Crain,Richard J. Traystman,Alane S. Kimes,Edythe D. London,Judy A. Klaus,Patricia D. Hurn +7 more
TL;DR: Long-term estradiol replacement within a low physiological range ameliorates ischemic brain injury in previously ovariectomized female rats, and this mechanism may not be identical and depends on long-term hormone augmentation in the female.