E
Edythe D. London
Researcher at University of California, Los Angeles
Publications - 492
Citations - 36481
Edythe D. London is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nicotinic agonist & Methamphetamine. The author has an hindex of 93, co-authored 482 publications receiving 33741 citations. Previous affiliations of Edythe D. London include Icahn School of Medicine at Mount Sinai & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers.
Edythe D. London,Steven M. Berman,Bradley Voytek,Sara L. Simon,M. Mandelkern,John Monterosso,Paul M. Thompson,Arthur L. Brody,Jennifer A. Geaga,Michael S. Hong,Kiralee M. Hayashi,Richard A. Rawson,Walter Ling +12 more
TL;DR: Dysfunction in the cingulate and insular cortices of recently abstinent MA abusers contribute to impaired vigilance and other cognitive functions requiring sustained attention.
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Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence.
TL;DR: Maladaptive decision making by methamphetamine users may reflect circuit-level dysfunction, underlying deficits in task-based activation, and Heightened resting-state connectivity within the mesocorticolimbic system, coupled with reduced prefrontal cortical connectivity, may create a bias toward reward-driven behavior over cognitive control in methamphetamine users.
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Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder.
Monique Ernst,David A. Luckenbaugh,Eric T. Moolchan,Michelle K. Leff,Rachel Allen,Neir Eshel,Edythe D. London,Alane S. Kimes +7 more
TL;DR: This 4-year longitudinal study captured the onset of substance use, not abuse, in healthy adolescents and in adolescents who have been diagnosed with attention-deficit/hyperactivity disorder.
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Morphine-induced metabolic changes in human brain. Studies with positron emission tomography and [fluorine 18]fluorodeoxyglucose.
Edythe D. London,E. P. Broussolle,Jonathan M. Links,Dean F. Wong,Nicola G. Cascella,Robert F. Dannals,Motoki Sano,Ronald I. Herning,Frederick Snyder,Lillian R. Rippetoe,Thomas J. K. Toung,Jerome H. Jaffe,Henry N. Wagner +12 more
TL;DR: Morphine sulfate effects (30 mg, intramuscularly) on cerebral glucose utilization and subjective self-reports were examined in 12 polydrug abusers by positron emission tomography and [fluorine 18]fluorodeoxyglucose in a double-blind placebo-controlled crossover study.
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Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder
Sanjaya Saxena,Eda Gorbis,Joseph O'Neill,S K Baker,M. Mandelkern,Karron M. Maidment,Susanna Chang,Noriko Salamon,Arthur L. Brody,Arthur L. Brody,Jeffrey M. Schwartz,Edythe D. London +11 more
TL;DR: Compared to controls, OCD patients showed significant bilateral decreases in normalized thalamic metabolism with intensive CBT but had a significant increase in right dorsal anterior cingulate cortex activity that correlated strongly with the degree of improvement in OCD symptoms, which improved robustly with treatment.