E
Edythe D. London
Researcher at University of California, Los Angeles
Publications - 492
Citations - 36481
Edythe D. London is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Nicotinic agonist & Methamphetamine. The author has an hindex of 93, co-authored 482 publications receiving 33741 citations. Previous affiliations of Edythe D. London include Icahn School of Medicine at Mount Sinai & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans.
Alane S. Kimes,Andrew G. Horti,Edythe D. London,Svetlana I. Chefer,Carlo Contoreggi,Monique Ernst,Phyllis Friello,Andrei O. Koren,Varughese Kurian,John A. Matochik,Olga A. Pavlova,D. Bruce Vaupel,Alexey G. Mukhin +12 more
TL;DR: Accumulated radioactivity was greatest in thalamus, intermediate in the midbrain, pons, cerebellum, and cortex; and least in white matter, which predicts that quantitative PET imaging of nAChRs in human brain with 2‐[18F]FA is feasible.
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Effects of nicotine on local cerebral glucose utilization in the rat
TL;DR: The findings indicate that the interaction of nicotine with specific binding sites is coupled to cerebral energy metabolism, and implicates various brain regions in the behavioral and physiological effects of nicotine.
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Local Cerebral Glucose Utilization During Development and Aging of the Fischer-344 Rat
TL;DR: A rise in cerebral glucose utilization with development from 1 to 3 months, a decline between 3 and 12 months, and a constancy in the second and third years that does not reflect reported senescence‐associated neurochemical and morphological cerebral changes are demonstrated.
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Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor.
TL;DR: The data suggest that [3H]pregnenolone sulfate binding sites are connected with or adjacent to the ionic channel of the GABAA receptor, but that they differ from picrotoxin recognition sites.
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Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain.
TL;DR: Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal; the findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters.