Edythe D. London

TL;DR: A program was developed to align positron emission tomography images from multiple studies on the same subject, finding that image alignment within 2.8 mm was essential to reduce variability of measured cerebral metabolic rates for glucose.

TL;DR: The authors conclude that the interaction of verapamil with morphine's respiratory depressant effects differs from the previously reported potentiation of morphine's antinociceptive and hypothermic actions.

TL;DR: The results inform the interpretation of steep discounting among smokers and suggest that treatment approaches could be tailored to the type of discounting behavior that smokers exhibit.

TL;DR: Gamma-vinyl-gamma-aminobutyric acid (GVG) treatment is generally well tolerated but not efficacious in attenuating the positive subjective effects of methamphetamine in the laboratory, and pharmacokinetic data indicate that GVG treatment did not alter methamphetamine or amphetamine plasma levels, and there was no association between methamphetamine or Amphetamine Plasma levels and peak cardiovascular effects.

TL;DR: The findings suggest that the fractional occupancy of receptors by endogenous dopamine in the lesioned putamen is nearly equal to that in the contralateral putamen, and the absolute number of receptors occupied by dopamine is greater in theLesioned than in the ContralateralPutamen.