E
Elias S.J. Arnér
Researcher at Karolinska Institutet
Publications - 208
Citations - 18978
Elias S.J. Arnér is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin reductase & Thioredoxin. The author has an hindex of 58, co-authored 192 publications receiving 16579 citations. Previous affiliations of Elias S.J. Arnér include City University of New York.
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Journal ArticleDOI
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.
Jonas Nordberg,Elias S.J. Arnér +1 more
TL;DR: The TrxR-catalyzed regeneration of several antioxidant compounds, including ascorbic acid (vitamin C), selenium-containing substances, lipoic acid, and ubiquinone are summarized.
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Physiological functions of thioredoxin and thioredoxin reductase.
Elias S.J. Arnér,Arne Holmgren +1 more
TL;DR: All mammalian thioredoxin reduct enzyme isozymes are homologous to glutathione reductase and contain a conserved C-terminal elongation with a cysteine-selenocysteine sequence forming a redox-active selenenylsulfide/selenolthiol active site and are inhibited by goldthioglucose and other clinically used drugs.
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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Irina Ingold,Carsten Berndt,Sabine Schmitt,Sebastian Doll,Gereon Poschmann,Katalin Buday,Antonella Roveri,Xiaoxiao Peng,Florencio Porto Freitas,Tobias Seibt,Lisa Mehr,Michaela Aichler,Axel Walch,Daniel Lamp,Martin Jastroch,Sayuri Miyamoto,Wolfgang Wurst,Wolfgang Wurst,Fulvio Ursini,Elias S.J. Arnér,Noelia Fradejas-Villar,Ulrich Schweizer,Hans Zischka,José Pedro Friedmann Angeli,Marcus Conrad +24 more
TL;DR: It is demonstrated that selenolate-based catalysis of the essential mammalian selenoprotein GPX4 is unexpectedly dispensable for normal embryogenesis and the survival of a specific type of interneurons emerges to exclusively depend on selenocysteine-containing GPX 4, thereby preventing fatal epileptic seizures.
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Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions
TL;DR: It is concluded that the intriguingly complex regulation and function of mammalian thioredoxin reductases within the cellular context and in intact mammals strongly suggests that their functions are highly fi ne-tuned with the many pathways involvingThioredoxins and thiOREDoxin-related proteins.
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Mammalian Deoxyribonucleoside Kinases
TL;DR: The physiologic metabolic role of the anabolic enzymes is discussed in relation to catabolic pathways, and alternative pathways for nucleoside analogue phosphorylation are surveyed, such as the phosphotransfer capacity of 5'-nucleotidase.