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Ester Gea-Mallorquí
Researcher at PSL Research University
Publications - 17
Citations - 529
Ester Gea-Mallorquí is an academic researcher from PSL Research University. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 5, co-authored 8 publications receiving 402 citations. Previous affiliations of Ester Gea-Mallorquí include University of Barcelona & Concordia University.
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Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors
Nicolas Ruffin,Ester Gea-Mallorquí,Flavien Brouiller,Mabel Jouve,Aymeric Silvin,Aymeric Silvin,Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Florent Ginhoux,Philippe Benaroch +10 more
TL;DR: It is shown that pre-DCs, but not other blood DC subsets, are susceptible to infection by HIV-1 in a Siglec-1–dependent manner, a unique functional feature that might represent a preferential relationship of this emerging cell type with viruses.
Journal ArticleDOI
Pre-clinical development of BCG.HIVACAT, an antibiotic-free selection strain, for HIV-TB pediatric vaccine vectored by Lysine Auxotroph of BCG
Narcís Saubi,Alice Mbewe-Mvula,Ester Gea-Mallorquí,Maximillian Rosario,Josep M. Gatell,Tomáš Hanke,Joan Joseph +6 more
TL;DR: T-cell immunogenicity of a novel, safer, GLP-compatible BCG-vectored vaccine using prototype immunogen HIVA is demonstrated and second generation immunogens derived from HIV-1 as well as other major pediatric pathogens can be constructed in a similar fashion to prime protective responses soon after birth.
Journal ArticleDOI
Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG.
Narcís Saubi,Ester Gea-Mallorquí,Pau Ferrer,C Hurtado,Sara Sánchez-Úbeda,Yoshiki Eto,Josep M. Gatell,Tomáš Hanke,Joan Joseph +8 more
TL;DR: This antibiotic-free plasmid selection system based on “double” auxotrophic complementation might be a new mycobacterial vaccine platform to develop not only recombinant BCG-based vaccines expressing second generation of HIV-1 immunogens but also other major pediatric pathogens to prime protective response soon after birth.
Journal ArticleDOI
The ability of an arginine to tryptophan substitution in Saccharomyces cerevisiae tRNA nucleotidyltransferase to alleviate a temperature-sensitive phenotype suggests a role for motif C in active site organization.
Mark E. Goring,Matthew Leibovitch,Ester Gea-Mallorquí,Shawn Karls,Francis Richard,Pamela J. Hanic-Joyce,Paul B.M. Joyce +6 more
TL;DR: The results, along with overexpression and deletion analyses, show that the ts phenotype of cca1-E189F does not arise from thermal instability of the variant tRNA nucleotidyltransferase but instead from the inability of a partially active enzyme to support growth only at higher temperatures.