N
Nicolas Ruffin
Researcher at Karolinska Institutet
Publications - 35
Citations - 1218
Nicolas Ruffin is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: T cell & Interleukin 21. The author has an hindex of 17, co-authored 29 publications receiving 965 citations. Previous affiliations of Nicolas Ruffin include PSL Research University & University of Paris.
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Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
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Role of miR-155 in the regulation of lymphocyte immune function and disease
Nabila Seddiki,Nabila Seddiki,Vedran Brezar,Vedran Brezar,Nicolas Ruffin,Nicolas Ruffin,Yves Levy,Yves Levy,Sanjay Swaminathan +8 more
TL;DR: This review summarizes what the authors have learned about miR‐155 in the regulation of lymphocyte responses at the cellular and molecular levels and in particular, focuses on the recent findings showing that this miRNA shapes the balance between tolerance and immunity.
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Impairment of B-cell functions during HIV-1 infection.
TL;DR: This review will highlight some of the pathways and molecular interactions leading to B-cell impairment prior to germinal center formation and B- cell activation mediated through the B-cells receptor in response to HIV-1 antigens.
Journal ArticleDOI
B-cell subset alterations and correlated factors in HIV-1 infection.
Simone Pensieroso,Laura Galli,Silvia Nozza,Nicolas Ruffin,Antonella Castagna,Giuseppe Tambussi,Bo Hejdeman,Donatella Misciagna,Agostino Riva,Mauro S. Malnati,Francesca Chiodi,Gabriella Scarlatti +11 more
TL;DR: It is indicated that viremia and nadir CD4+ T cells are important prognostic markers of B-cell perturbations and provide evidence that resting memory B- cell depletion during chronic infection is not reverted upon successful antiretroviral therapy.
Journal ArticleDOI
Myeloid Cell Interaction with HIV: A Complex Relationship.
TL;DR: An overview of the HIV–macrophage interaction along the multiple stages of the viral life cycle is provided, extending when pertinent such observations to additional myeloid cell types such as dendritic cells or blood monocytes.