Fatemeh Haghighi

TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.

TL;DR: The enrichment of Regulatory sequences in the relatively small unmethylated compartment suggests that cytosine methylation constrains the effective size of the genome through the selective exposure of regulatory sequences.

TL;DR: It is concluded that methylation is the default state of most CpG dinucleotides in the mammalian genome and that a combination of local dinucleotide frequencies, the interaction of repeated sequences, and the presence or absence of histone variants or modifications shields a population of C pG sites from DNA methyltransferases that lack intrinsic sequence specificity.

TL;DR: It is demonstrated that DNA methylation abnormalities arising in the sperm of old fathers are a plausible mechanism to explain some of the risks that APA poses to resulting offspring.

TL;DR: Higher 5‐HTT CpG methylation, but not rh5‐HTTLPR genotype, exacerbated the effects of early life stress on behavioral stress reactivity in infants, which may contribute to the risk for mood disorders observed in ‘high‐risk’5‐ HTTLPR carriers.