F
Ferdouse Begum
Researcher at Johns Hopkins University
Publications - 29
Citations - 1649
Ferdouse Begum is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Genome-wide association study & COPD. The author has an hindex of 15, co-authored 27 publications receiving 1421 citations. Previous affiliations of Ferdouse Begum include University of Pittsburgh & Johns Hopkins University School of Medicine.
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Comprehensive literature review and statistical considerations for GWAS meta-analysis
TL;DR: In this paper, a systematic search from PubMed and manual collection to obtain 620 genomic meta-analysis papers, of which 333 microarray metaanalysis papers are summarized as the basis of this paper and the other 249 GWAS meta analysis papers are discussed in the next companion paper.
SURVEY AND SUMMARY Comprehensive literature review and statistical considerations for GWAS meta-analysis
TL;DR: This article systematically reviews the GWAS meta-analysis literature, highlighting methodology and software options and reviewing methods that have been used in real studies, and illustrating differences among methods using a case study.
Journal ArticleDOI
Identification of Functional Variants for Cleft Lip with or without Cleft Palate in or near PAX7, FGFR2, and NOG by Targeted Sequencing of GWAS Loci
Elizabeth J. Leslie,Margaret A. Taub,Huan Liu,Huan Liu,Karyn Meltz Steinberg,Daniel C. Koboldt,Qunyuan Zhang,Jenna C. Carlson,Jacqueline B. Hetmanski,Hang Wang,David E. Larson,Robert S. Fulton,Youssef A. Kousa,Walid D. Fakhouri,Ali Naji,Ingo Ruczinski,Ferdouse Begum,Margaret M. Parker,Tamara Busch,Jennifer Standley,Jennifer Rigdon,Jacqueline T. Hecht,Alan F. Scott,George L. Wehby,Kaare Christensen,Andrew E. Czeizel,Frederic W.-B. Deleyiannis,Brian C. Schutte,Richard K. Wilson,Robert A. Cornell,Andrew C. Lidral,George M. Weinstock,Terri H. Beaty,Mary L. Marazita,Jeffrey C. Murray +34 more
TL;DR: This targeted sequencing study provides strong functional evidence implicating several specific variants as primary contributory risk alleles for nonsyndromic clefting in humans.
Journal ArticleDOI
Genome-wide Association Scan for Childhood Caries Implicates Novel Genes
John R. Shaffer,Xiaojing Wang,Eleanor Feingold,Myoungkeun Lee,Ferdouse Begum,Daniel E. Weeks,Karen T. Cuenco,M. Michael Barmada,Steven Wendell,David R. Crosslin,Cathy C. Laurie,Kimberley F Doheny,Elizabeth W. Pugh,Qi Zhang,Bjarke Feenstra,Frank Geller,Heather A. Boyd,H. Zhang,Mads Melbye,Jeffrey C. Murray,Robert J. Weyant,Richard J. Crout,Daniel W. McNeil,Steven M. Levy,Rebecca L. Slayton,Marcia C. Willing,Barbara Broffitt,Alexandre R. Vieira,Mary L. Marazita +28 more
TL;DR: It is reinforced the complexity of dental caries, suggesting that numerous loci, mostly having small effects, are involved in cariogenesis, and verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental carie.
Journal ArticleDOI
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
Steven R. Brant,David T. Okou,Claire L. Simpson,Claire L. Simpson,David J. Cutler,Talin Haritunians,Jonathan P. Bradfield,Pankaj Chopra,Jarod Prince,Ferdouse Begum,Archana Kumar,Chengrui Huang,Suresh Venkateswaran,Lisa W. Datta,Zhi Wei,Kelly A. Thomas,Lisa J. Herrinton,Jan Micheal A. Klapproth,Antonio Quiros,Jenifer Seminerio,Zhenqiu Liu,Jonathan Steven Alexander,Robert N. Baldassano,Sharon Dudley-Brown,Raymond K. Cross,Themistocles Dassopoulos,Lee A. Denson,Tanvi Dhere,Gerald W. Dryden,John S. Hanson,Jason K. Hou,Sunny Z. Hussain,Jeffrey S. Hyams,Kim L. Isaacs,Howard A. Kader,Michael D. Kappelman,Jeffry Katz,Richard Kellermayer,Barbara S. Kirschner,John F. Kuemmerle,John H. Kwon,Mark Lazarev,Ellen Li,David R. Mack,Peter J. Mannon,Dedrick E. Moulton,Rodney D. Newberry,Bankole O. Osuntokun,Ashish S. Patel,Shehzad Ahmed Saeed,Stephan R. Targan,John F. Valentine,Ming-Hsi Wang,Martin Zonca,John D. Rioux,Richard H. Duerr,Mark S. Silverberg,Judy H. Cho,Hakon Hakonarson,Michael E. Zwick,Dermot P.B. McGovern,Subra Kugathasan +61 more
TL;DR: The detection of variants associated with IBD risk in only people of African descent demonstrates the importance of studying the genetics of IBD and other complex diseases in populations beyond those of European ancestry.