G
G. James Gatter
Researcher at Massachusetts Institute of Technology
Publications - 6
Citations - 2009
G. James Gatter is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Downregulation and upregulation & T-cell receptor. The author has an hindex of 4, co-authored 4 publications receiving 1369 citations. Previous affiliations of G. James Gatter include Ragon Institute of MGH, MIT and Harvard & Broad Institute.
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Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly G. K. Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Constantine N. Tzouanas,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Blake M. Hauser,Jared Feldman,Jared Feldman,Christoph Muus,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,G. James Gatter,G. James Gatter,Marko Vukovic,Faith Taliaferro,Faith Taliaferro,Benjamin E. Mead,Zhiru Guo,Jennifer P. Wang,Delphine Gras,Magali Plaisant,Meshal Ansari,Ilias Angelidis,Heiko Adler,Jennifer M.S. Sucre,Chase J. Taylor,Brian M. Lin,Avinash Waghray,Vanessa Mitsialis,Vanessa Mitsialis,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Victor Tkachev,Christopher W. Peterson,Christopher W. Peterson,Alison Yu,Alison Yu,Hengqi Betty Zheng,Hengqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Philana Ling Lin,Colin D. Bingle,Scott B. Snapper,Scott B. Snapper,Jonathan A. Kropski,Jonathan A. Kropski,Fabian J. Theis,Herbert B. Schiller,Laure-Emmanuelle Zaragosi,Pascal Barbry,Alasdair Leslie,Alasdair Leslie,Hans-Peter Kiem,Hans-Peter Kiem,JoAnne L. Flynn,Sarah M. Fortune,Sarah M. Fortune,Sarah M. Fortune,Bonnie Berger,Robert W. Finberg,Leslie S. Kean,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes,Nicholas E. Banovich,Alvis Brazma,Tushar J. Desai,Thu Elizabeth Duong,Oliver Eickelberg,Christine S. Falk,Michael Farzan,Ian A. Glass,Muzlifah Haniffa,Peter Horvath,Deborah T. Hung,Naftali Kaminski,Mark A. Krasnow,Malte Kühnemund,Robert Lafyatis,Haeock Lee,Sylvie Leroy,Sten Linnarson,Joakim Lundeberg,Kerstin B. Meyer,Alexander V. Misharin,Martijn C. Nawijn,Marko Nikolic,Dana Pe'er,Joseph E. Powell,Stephen R. Quake,Jay Rajagopal,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Mauricio Rojas,Orit Rosen,Kourosh Saeb-Parsy,Christos Samakovlis,Herbert B. Schiller,Joachim L. Schultze,Max A. Seibold,Douglas P. Shepherd,Jason R. Spence,Avrum Spira,Xin Sun,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Ramnik J. Xavier,Yan Xu,Kun Zhang +135 more
TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues
Carly Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Jared Feldman,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,Marko Vukovic,Constantine N. Tzouanas,Faith Taliaferro,Zhiru Guo,Jennifer P. Wang,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Alison Yu,Henqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Bonnie Berger,Alasdair Leslie,JoAnne L. Flynn,Sarah M. Fortune,Robert W. Finberg,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes +44 more
TL;DR: In this paper, the authors leverage human and non-human primate single-cell RNA-sequencing (scRNA-seq) datasets to uncover the cell subsets that may serve as cellular targets of SARS-CoV-2.
Journal ArticleDOI
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Michael H. Askenase,Brittany A. Goods,Hannah E. Beatty,Arthur F. Steinschneider,Sofia E. Velazquez,Artem Osherov,Margaret J. Landreneau,Shaina Carroll,Tho B. Tran,Victor S. Avram,Riley S. Drake,G. James Gatter,Jordan Massey,Saravanan S. Karuppagounder,Rajiv R. Ratan,Charles C. Matouk,Kevin N. Sheth,Wendy C. Ziai,Adrian R Parry-Jones,Issam A. Awad,Mario Zuccarello,Richard E. Thompson,Jesse Dawson,Daniel F. Hanley,J. Christopher Love,J. Christopher Love,Alex K. Shalek,Lauren H Sansing,ICHseq investigators +28 more
TL;DR: In this paper, a clinical trial of minimally invasive neurosurgery for patients with intracerebral hemorrhage (ICH), a severely disabling subtype of stroke, was used to investigate the dynamics of inflammation at the site of brain injury over time.
Journal ArticleDOI
A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood.
Maya Sangesland,Ashraf S. Yousif,Larance Ronsard,Samuel W. Kazer,Alex Lee Zhu,G. James Gatter,Matthew R. Hayward,Ralston M. Barnes,Maricel Quirindongo-Crespo,Daniel K. Rohrer,Nils Lonberg,Douglas S. Kwon,Douglas S. Kwon,Alex K. Shalek,Daniel Lingwood +14 more
TL;DR: A broad-spectrum anti-LPS response is revealed in which germline-encoded CDRs naturally hardwire the human antibody repertoire for recognition of a conserved microbial target.
Journal ArticleDOI
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
Swati Jaiswal,Sarah K. Nyquist,Shayla Boyce,Tasneem Jivanjee,Samira Ibrahim,Joshua D. Bromley,G. James Gatter,Hannah P. Gideon,K V Patel,Sharie Keanne C. Ganchua,Bonnie Berger,Sarah M. Fortune,JoAnne L. Flynn,Alex K. Shalek,Samuel M. Behar +14 more
TL;DR: The genomic organization of the cynomolgus Macaca fascicularis macaque has great similarity with the rhesus macaque and they shared > 90% sequence similarities with the human TCR repertoire.