A
Ashraf S. Yousif
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 24
Citations - 2321
Ashraf S. Yousif is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Antigen & Biology. The author has an hindex of 10, co-authored 21 publications receiving 1590 citations. Previous affiliations of Ashraf S. Yousif include Kyoto University & Massachusetts Institute of Technology.
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Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly G. K. Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Constantine N. Tzouanas,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Blake M. Hauser,Jared Feldman,Jared Feldman,Christoph Muus,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,G. James Gatter,G. James Gatter,Marko Vukovic,Faith Taliaferro,Faith Taliaferro,Benjamin E. Mead,Zhiru Guo,Jennifer P. Wang,Delphine Gras,Magali Plaisant,Meshal Ansari,Ilias Angelidis,Heiko Adler,Jennifer M.S. Sucre,Chase J. Taylor,Brian M. Lin,Avinash Waghray,Vanessa Mitsialis,Vanessa Mitsialis,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Victor Tkachev,Christopher W. Peterson,Christopher W. Peterson,Alison Yu,Alison Yu,Hengqi Betty Zheng,Hengqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Philana Ling Lin,Colin D. Bingle,Scott B. Snapper,Scott B. Snapper,Jonathan A. Kropski,Jonathan A. Kropski,Fabian J. Theis,Herbert B. Schiller,Laure-Emmanuelle Zaragosi,Pascal Barbry,Alasdair Leslie,Alasdair Leslie,Hans-Peter Kiem,Hans-Peter Kiem,JoAnne L. Flynn,Sarah M. Fortune,Sarah M. Fortune,Sarah M. Fortune,Bonnie Berger,Robert W. Finberg,Leslie S. Kean,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes,Nicholas E. Banovich,Alvis Brazma,Tushar J. Desai,Thu Elizabeth Duong,Oliver Eickelberg,Christine S. Falk,Michael Farzan,Ian A. Glass,Muzlifah Haniffa,Peter Horvath,Deborah T. Hung,Naftali Kaminski,Mark A. Krasnow,Malte Kühnemund,Robert Lafyatis,Haeock Lee,Sylvie Leroy,Sten Linnarson,Joakim Lundeberg,Kerstin B. Meyer,Alexander V. Misharin,Martijn C. Nawijn,Marko Nikolic,Dana Pe'er,Joseph E. Powell,Stephen R. Quake,Jay Rajagopal,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Mauricio Rojas,Orit Rosen,Kourosh Saeb-Parsy,Christos Samakovlis,Herbert B. Schiller,Joachim L. Schultze,Max A. Seibold,Douglas P. Shepherd,Jason R. Spence,Avrum Spira,Xin Sun,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Ramnik J. Xavier,Yan Xu,Kun Zhang +135 more
TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
Journal ArticleDOI
Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement
Giuseppe Lofano,Matthew J. Gorman,Ashraf S. Yousif,Wen-Han Yu,Wen-Han Yu,Julie M. Fox,Anne-Sophie Dugast,Margaret E. Ackerman,Todd J. Suscovich,Joshua A. Weiner,Dan H. Barouch,Dan H. Barouch,Hendrik Streeck,Susan J. Little,Davey M. Smith,Davey M. Smith,Douglas D. Richman,Douglas D. Richman,Douglas A. Lauffenburger,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Michael S. Diamond,Galit Alter +23 more
TL;DR: A direct role for altered Fc profile/complement interactions in shaping the maturation of the humoral immune response is pointed to, providing insights into how GC activity may be enhanced to drive affinity maturation in next-generation vaccine approaches.
Journal ArticleDOI
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
TL;DR: Brd4 serves as a chromatin platform required for the recruitment of repair components during CSR and general DNA damage and is shown to be critical for nonhomologous end-joining (NHEJ) repair of AID- and I-SceI-induced DNA breaks.
Journal ArticleDOI
Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus.
Maya Sangesland,Larance Ronsard,Samuel W. Kazer,Julia Bals,Seyhan Boyoglu-Barnum,Ashraf S. Yousif,Ralston M. Barnes,Jared Feldman,Maricel Quirindongo-Crespo,Patrick M. Mctamney,Daniel K. Rohrer,Nils Lonberg,Bryce Chackerian,Barney S. Graham,Masaru Kanekiyo,Alex K. Shalek,Daniel Lingwood +16 more
TL;DR: The results indicate that the human repertoire could, in principle, support germline-encoded bnAb elicitation using a single recombinant hemagglutinin immunogen.
Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues
Carly Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Jared Feldman,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,Marko Vukovic,Constantine N. Tzouanas,Faith Taliaferro,Zhiru Guo,Jennifer P. Wang,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Alison Yu,Henqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Bonnie Berger,Alasdair Leslie,JoAnne L. Flynn,Sarah M. Fortune,Robert W. Finberg,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes +44 more
TL;DR: In this paper, the authors leverage human and non-human primate single-cell RNA-sequencing (scRNA-seq) datasets to uncover the cell subsets that may serve as cellular targets of SARS-CoV-2.