Sarah K. Nyquist

TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.

TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.

TL;DR: An experimental and computational methodology that uses scRNA-seq to characterize dynamic cellular programs and their molecular drivers, and applies it to HIV infection provides insights into the initial immune responses during early infection that might shape future outcomes.

TL;DR: The authors identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance.