G
Gang Wang
Researcher at Cornell University
Publications - 169
Citations - 11789
Gang Wang is an academic researcher from Cornell University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 49, co-authored 123 publications receiving 10419 citations. Previous affiliations of Gang Wang include University of Massachusetts Amherst & Dartmouth College.
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Journal ArticleDOI
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek,Akin Akinc,Birgit Bramlage,Klaus Charisse,Rainer Constien,Mary Donoghue,Sayda Elbashir,Anke Geick,Philipp Hadwiger,Jens Harborth,Matthias John,Venkitasamy Kesavan,Gary Lavine,Rajendra K. Pandey,Timothy Racie,Kallanthottathil G. Rajeev,Ingo Röhl,Ivanka Toudjarska,Gang Wang,Silvio Wuschko,David Bumcrot,Victor Koteliansky,Stefan Limmer,Muthiah Manoharan,Hans-Peter Vornlocher +24 more
TL;DR: In this article, chemically modified short interfering RNAs (siRNAs) were used to silence an endogenous gene encoding apolipoprotein B (apoB) after intravenous injection in mice.
Journal ArticleDOI
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Christian Wolfrum,Shuanping Shi,K. Narayanannair Jayaprakash,Muthusamy Jayaraman,Gang Wang,Rajendra K. Pandey,Kallanthottathil G. Rajeev,Tomoko Nakayama,Klaus Charrise,Esther Ndungo,Tracy Zimmermann,Victor Koteliansky,Muthiah Manoharan,Markus Stoffel,Markus Stoffel,Markus Stoffel +15 more
TL;DR: It is shown that conjugation to bile acids and long-chain fatty acids, in addition to cholesterol, mediates siRNA uptake into cells and gene silencing in vivo and can be exploited to optimize therapeutic siRNA delivery.
Journal ArticleDOI
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
Maria Frank-Kamenetsky,Aldo Grefhorst,Norma N. Anderson,Timothy Racie,Birgit Bramlage,Akin Akinc,David Butler,Klaus Charisse,Robert Dorkin,Yupeng Fan,Christina Gamba-Vitalo,Philipp Hadwiger,Muthusamy Jayaraman,Matthias John,K. Narayanannair Jayaprakash,Martin Maier,Lubomir Nechev,Kallanthottathil G. Rajeev,Timothy Read,Ingo Röhl,Jürgen Soutschek,Pamela Tan,Jamie Wong,Gang Wang,Tracy Zimmermann,Antonin de Fougerolles,Hans-Peter Vornlocher,Robert Langer,Daniel G. Anderson,Muthiah Manoharan,Victor Koteliansky,Jay D. Horton,Kevin Fitzgerald +32 more
TL;DR: PCSK9 targeting with RNAi therapeutics as an approach to specifically lower LDLc is validated, paving the way for the development of PCSK9-lowering agents as a future strategy for treatment of hypercholesterolemia.
Journal ArticleDOI
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
Dong Niu,Hong-Jiang Wei,Lin Lin,Haydy George,Tao Wang,I-Hsiu Lee,Hong-Ye Zhao,Yong Wang,Yinan Kan,Ellen Shrock,Emal Lesha,Gang Wang,Yonglun Luo,Yubo Qing,Deling Jiao,Heng Zhao,Xiaoyang Zhou,Shouqi Wang,Hong Wei,Marc Güell,George M. Church,George M. Church,Luhan Yang +22 more
TL;DR: The value ofPERV inactivation to prevent cross-species viral transmission is highlighted and the successful production of PERV-inactivated animals to address the safety concern in clinical xenotransplantation are demonstrated.
Journal ArticleDOI
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
Bin Zhou,Leah B. Honor,Huamei He,Qing Ma,Jin-Hee Oh,Jin-Hee Oh,Catherine Butterfield,Ruei-Zeng Lin,Juan M. Melero-Martin,Elena Dolmatova,Heather S. Duffy,Alexander von Gise,Pingzhu Zhou,Yong Wu Hu,Gang Wang,Bing Zhang,Lianchun Wang,Jennifer L. Hall,Marsha A. Moses,Francis X. McGowan,William T. Pu +20 more
TL;DR: Genetic fate-mapping approaches in mice indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection.