G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Influence of hospitalization and placebo therapy on blood pressure and sympathetic function in essential hypertension.
TL;DR: The decline in blood pressure in essential hypertensives following hospitalization may result from: 1) regression toward the mean; 2) reduction of anxiety as patients habituate to a new enrironment; 3) the placebo effect of medication; and 4) an independent effect of hospitalization itself.
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Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs
Xuanwen Li,Susanne Fries,Ruizhi Li,John A. Lawson,Kathleen J. Propert,Scott L. Diamond,Ian A. Blair,Garret A. FitzGerald,Tilo Grosser +8 more
TL;DR: A MS assay was developed to quantitate precisely the interaction of aspirin with NSAIDs by measuring the target engagement of aspirin directly by MS and developed a novel assay of cyclooxygenase-1 (COX-1) acetylation in platelets isolated from volunteers who were administered aspirin.
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Allergen-Stimulated Release of Mediators into Sheep Bronchoalveolar Lavage Fluid: Effect of Cyclooxygenase Inhibition
Ryszard Dworski,James R. Sheller,Nancy Wickersham,J. A. Gates,Kenneth L. Brigham,L. J. Roberts,Garret A. FitzGerald +6 more
TL;DR: Eicosanoids are formed promptly in vivo in sheep after allergen instillation: inhibition of cyclooxygenase results in augmented generation of leukotrienes in the airways of sensitive sheep in response to antigen challenge.
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Two polymorphisms in the human lipoprotein lipase (LPL) gene.
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A Pilot Characterization of the Human Chronobiome.
Carsten Skarke,Nicholas F. Lahens,Seth D. Rhoades,Amy E. Campbell,Kyle Bittinger,Aubrey Bailey,Christian Hoffmann,Christian Hoffmann,Randal S. Olson,Lihong Chen,Guangrui Yang,Thomas S. Price,Jason H. Moore,Frederic D. Bushman,Casey S. Greene,Gregory R. Grant,Aalim M. Weljie,Garret A. FitzGerald +17 more
TL;DR: Data from remote sensors, physiological and multi-omics analyses are integrated to assess the feasibility of detecting time dependent signals - the chronobiome – despite the “noise” attributable to the behavioral differences of free-living human volunteers.