G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Identification of Two Major F2 Isoprostanes, 8,12-Iso- and 5-epi-8,12-Iso-isoprostane F2α-VI, in Human Urine
John A. Lawson,Hongwei Li,Joshua Rokach,Mustafa Adiyaman,Seongwoo Hwang,Subhash P. Khanapure,Garret A. FitzGerald +6 more
TL;DR: The identification in human urine of two more isomers of F2-iP, 8,12-iso-iPF2α-VI and 5-epi-8,12 -iso- iPF2 α-VI, using high performance liquid chromatography/tandem mass spectrometry and gas Chromatography/mass Spectrometry.
Journal ArticleDOI
Internalization and sequestration of the human prostacyclin receptor.
TL;DR: The hIP is sequestered in response to agonist activation via a PKC-independent pathway that is distinct from desensitization, indicating that GRKs and arrestins do not play a role in hIP trafficking.
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COX-2–Dependent Cardiac Failure in Gh/tTG Transgenic Mice
Zhibing Zhang,Roberta Vezza,Theodore Plappert,Peter McNamara,John A. Lawson,Sandra Austin,Domenico Praticò,Martin St. John Sutton,Garret A. FitzGerald +8 more
TL;DR: Gh/tTG activation regulates expression of COX-2 and its products may differentially modulate cardiomyocyte commitment to cell death or survival, and formation of PGI2 by the same isozyme ameliorates the phenotype.
Journal ArticleDOI
Timing the Microbes: The Circadian Rhythm of the Gut Microbiome.
Xue Liang,Garret A. FitzGerald +1 more
TL;DR: The time-of-day–dependent compositional and functional structure within the gut microbial community, how it is regulated by the host, and how it reciprocally influences the host circadian clock are discussed.
Journal ArticleDOI
Role of Prostacyclin versus Peroxisome Proliferator-Activated Receptor β Receptors in Prostacyclin Sensing by Lung Fibroblasts
Ferhana Y. Ali,Karine Egan,Garret A. FitzGerald,Béatrice Desvergne,Walter Wahli,David Bishop-Bailey,Timothy D. Warner,Jane Mitchell +7 more
TL;DR: It is demonstrated that the antiproliferative effects of treprostinil sodium are mediated by PPARbeta and not IP in lung fibroblasts, suggesting that some of the local, longer-term benefits of tre Prostacyclin mimetics on reducing the remodeling associated with pulmonary hypertension may be mediated byPPARbeta.