G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal Article
Biological clocks: a cardiovascular perspective
TL;DR: The present review provides a short overview of the molecular basis of the oscillator, and discusses the current understanding of the role of clocks in cardiovascular physiology and summarizes potential entraining signals of relevance to cardiovascular function.
Journal ArticleDOI
Prostaglandin E2 Is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis.
Trista E. North,Trista E. North,Wolfram Goessling,Wolfram Goessling,Kamden R. Kopani,Kamden R. Kopani,Claudia Lengerke,Carl R. Walkley,Carl R. Walkley,Allegra M. Lord,Allegra M. Lord,Il-ho Jang,Tilo Grosser,Garret A. FitzGerald,George Q. Daley,Stuart H. Orkin,Stuart H. Orkin,Leonard I. Zon,Leonard I. Zon +18 more
TL;DR: Ex vivo treatment of murine bone marrow with dmPGE2 resulted in a 2-fold increase in CFU-S number and enhanced the frequency of multi-lineage engrafting HSCs more than 3-fold in a limiting dilution competitive repopulation assay, indicating that PGE2 also functions in regulating adult marrow HSC homeostasis.
Journal Article
Thromboxane biosynthesis and antagonism in humans.
TL;DR: Combined administration of TX antagonists and TX synthase inhibitors offers a theoretical advantage over aspirin which may ultimately justify their place in the therapy of vascular disease in humans.
Journal Article
Eicosanoid biosynthesis in human diabetes mellitus.
Posted ContentDOI
Loss of Circadian Protection in Adults Exposed to Neonatal Hyperoxia
Yasmine Issah,Amruta Naik,Soon Yew Tang,Kaitlyn Forrest,Thomas G Brooke,Nicholas F. Lahens,Katherine N. Theken,Amita Sehgal,George S Worthen,George S Worthen,Garret A. FitzGerald,Shaon Sengupta +11 more
TL;DR: It is shown that neonatal hyperoxia abrogates the circadian protection from Influenza infection in recovered adults, and a novel role for the circadian clock in AT2 clock in mediating long-term effects of early life exposures to the lungs.