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Garret A. FitzGerald

Researcher at University of Pennsylvania

Publications -  573
Citations -  64984

Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.

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Journal ArticleDOI

Estimated rate of prostacyclin secretion into the circulation of normal man.

Garret A. FitzGerald, +3 more
- 01 Nov 1981 - 
TL;DR: The much lower estimates obtained in this study suggest that endogenous PGI2 is unlikely to act as a circulating antiplatelet agent in healthy man.
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11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation

Francesca Catella, +3 more
- 01 Aug 1986 - 
TL;DR: It is established that whole blood possesses a minor capacity to form 11-dehydro-TXB2, attributable to nonenzymatic formation in erythrocytes, and results indicate that plasma TXB2 is readily confounded by platelet activation ex vivo.
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Effects of vitamin E on lipid peroxidation in healthy persons.

Emma A. Meagher, +4 more
- 07 Mar 2001 - 
TL;DR: The results question the rationale for vitamin E supplementation in healthy individuals and specific quantitative indices of oxidative stress in vivo should be considered as entry criteria and for dose selection in clinical trials of antioxidant drugs and vitamins in human disease.
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8-Epi PGF2α Generation During Coronary Reperfusion

Norman Delanty, +8 more
- 03 Jun 1997 - 
TL;DR: The hypothesis that free radical generation occurs during myocardial reperfusion is supported and measurement of isoprostane production may serve as a noninvasive index of oxidative stress.
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Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress

Domenico Praticò, +5 more
- 01 Dec 1998 - 
TL;DR: Increased urinary iPF2alpha-III is consistent with the hypothesis that oxidative stress occurs in COPD and provides a basis for dose finding and evaluation of antioxidant therapy in the treatment of this disease.