G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Localization of distinct F2-isoprostanes in human atherosclerotic lesions.
Domenico Praticò,Luigi Iuliano,Alessandro Mauriello,Luigi Giusto Spagnoli,John A. Lawson,J Rokach,Jacques Maclouf,Francesco Violi,Garret A. FitzGerald +8 more
TL;DR: The results indicate that 8-epi PGF2alpha and IPF2alpha-I, two distinct F2-isoprostanes and markers of oxidative stress in vivo, are present in human atherosclerotic plaque.
Journal Article
Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man.
Zhaoyue Wang,G. Ciabattoni,Christophe Créminon,John A. Lawson,Garret A. FitzGerald,Carlo Patrono,Jacques Maclouf +6 more
TL;DR: Preliminary results showed that excretion increased as a function of age, and an enzyme immunoassays and a radioimmunoassay were developed for measuring urinary concentrations of 8-epi-PGF2 alpha by raising antibodies against this compound.
Journal ArticleDOI
Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity.
Domenico Praticò,Christopher M. Clark,Virginia M.-Y. Lee,John Q. Trojanowski,Joshua Rokach,Garret A. FitzGerald +5 more
TL;DR: Elevated levels in the urine, blood, and cerebrospinal fluid of patients with Alzheimer's disease that correlated with measures of cognitive and functional impairment, established biomarkers of AD pathology and the number of apolipoprotein E ε4 alleles suggest that 8,12‐iso‐iPF2α‐VI is a useful biomarker of oxidative damage in AD.
Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic
Masayuki Wada,Cynthia J. DeLong,Yu H. Hong,Caroline Jill Rieke,In-Seok Song,Ranjinder S. Sidhu,Chong Yuan,Mark Warnock,Alvin H. Schmaier,Chieko Yokoyama,M. Smyth,Stephen J. Wilson,Garret A. FitzGerald,R. Michael Garavito,Xin Sui,John W. Regan,William L. Smith +16 more
TL;DR: In vitro specificities of prostanoid enzymes and receptors toward EPA-derived, 3-series versus AA- derived, 2-series prostanoids substrates and products are reported and biochemical data predict that increasing phospholipid EPA/AA ratios in cells would dampen prostanoidal signaling.
Journal ArticleDOI
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
TL;DR: The results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression.