G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension.
TL;DR: In this paper, a non-invasive approach, measurement of the urinary metabolite 2,3-dinor-6-keto-prostaglandin F1 alpha was used to determine prostacyclin biosynthesis in pregnant subjects at risk of developing pregnancy-induced hypertension.
Journal ArticleDOI
Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α
TL;DR: A major component of 8-epi PGF2α formed in serum by healthy volunteers was shown to be sensitive to inhibition by aspirin ex vivo, and may be formed as a PG by human platelets.
Journal ArticleDOI
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
Luis A. Garza,Yaping Liu,Zaixin Yang,Brinda Alagesan,John A. Lawson,Scott M. Norberg,Dorothy E. Loy,Tailun Zhao,Hanz Blatt,David C. Stanton,Lee Carrasco,Gurpreet Ahluwalia,Susan M. Fischer,Garret A. FitzGerald,George Cotsarelis +14 more
TL;DR: PGD2 is defined as an inhibitor of hair growth in AGA and the PGD2-GPR44 pathway is suggested as a potential target for treatment, providing new insight into the pathogenesis of AGA.
Journal ArticleDOI
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation
B. F. McAdam,I. A. Mardini,Aida Habib,Anne Burke,John A. Lawson,Shiv Kapoor,Garret A. FitzGerald +6 more
TL;DR: Although COX-2 predominates, both COX isozymes are induced and contribute to the prostaglandin response to LPS in humans, and COX activation contributes undetectably to lipid peroxidation induced by LPS.
Journal ArticleDOI
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Guangrui Yang,Lihong Chen,Gregory R. Grant,Georgios K. Paschos,Wen-Liang Song,Erik S. Musiek,Vivian S. Lee,Sarah McLoughlin,Tilo Grosser,George Cotsarelis,Garret A. FitzGerald +10 more
TL;DR: It is shown that the developmental timing of Bmal1 expression influences the circadian clock’s effects on aging and survival, and the systemic role of the molecular clock in the biology of aging requires reinvestigation in order to increase the likelihood of translation for preclinical studies of the aging process.