G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates.
Laurence A. Harker,Andrew B. Kelly,Stephen R. Hanson,W C Krupski,A Bass,B Osterud,Garret A. FitzGerald,S H Goodnight,W E Connor +8 more
TL;DR: In nonhuman primates, dietary n-3FAs in high doses eliminate both vascular thrombus formation and vascular lesion formation after mechanical vascular injury while largely sparing hemostatic function and modestly reducing blood thrombotic responses.
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F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.
TL;DR: Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress, which might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants.
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Peripheral Circadian Clocks in the Vasculature
TL;DR: It is now accepted that peripheral cells, including those of the cardiovascular system, contain a circadian clock similar to that in the SCN, and biological responses under the control of the molecular clock might interact with environmental cues to influence the phenotype of human cardiovascular disease.
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Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha.
TL;DR: The human FP may be activated specifically, by the free radical-catalyzed F2 isoprostane, 12-iso-PGF2alpha, in addition to the cyclooxygenase product, PGF2 alpha, where oxidant stress and augmented prostaglandin biosynthesis coincide.
Journal Article
Enhanced lipid peroxidation in hepatic cirrhosis.
Domenico Pratico,Luigi Iuliano,Stefania Basili,Domenico Ferro,Caterina Camastra,Corrado Cordova,Garret A. FitzGerald,Francesco Violi +7 more
TL;DR: It is demonstrated that lipid peroxidation is increased in vivo in patients with cirrhosis and suggests that oxidant stress might contribute to the deterioration of liver disease.