G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Oral Delivery of Anticoagulant Doses of Heparin A Randomized, Double-Blind, Controlled Study in Humans
Robert A. Baughman,Shiv Kapoor,Rajesh K. Agarwal,James Kisicki,Francesca Catella-Lawson,Garret A. FitzGerald +5 more
TL;DR: Heparin, administered orally in combination with the delivery agent SNAC, produces significant elevations in 4 indexes of anticoagulant effect in healthy human volunteers, establishing the feasibility of oral delivery of anticonvulsant doses of heparin in humans and may have broader implications for the absorption of macromolecules.
Journal ArticleDOI
Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.
Paloma Guillem-Llobat,Melania Dovizio,Annalisa Bruno,Emanuela Ricciotti,Valerio Cufino,Angela Sacco,Rosalia Grande,Sara Alberti,Vincenzo Arena,Mariangela Cirillo,Carlo Patrono,Garret A. FitzGerald,Dieter Steinhilber,Alessandro Sgambato,Paola Patrignani +14 more
TL;DR: Targeting platelet COX-1 with low-dose aspirin exerts an antimetastatic action by averting the stem cell mimicry of cancer cells associated with enhanced proaggregatory effects induced by platelet-tumor cell interactions.
Journal ArticleDOI
The biochemical pharmacology of thromboxane synthase inhibition in man.
TL;DR: Investigations of their efficacy in human disease have proven disappointing, and compounds of longer duration of action are required to test the hypothesis that thromboxane synthase inhibitors are efficacious inhuman disease.
Journal ArticleDOI
Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets.
TL;DR: It is demonstrated that thromboxane biosynthesis is increased in pregnancy and the increase is mainly platelet derived and is consistent with increased platelet activation throughout pregnancy.
Journal ArticleDOI
COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis.
Alysia Kern Lovgren,Leigh A. Jania,John M. Hartney,Kelly K. Parsons,Laurent P. Audoly,Garret A. FitzGerald,Stephen L. Tilley,Beverly H. Koller +7 more
TL;DR: It is suggested that prostacyclin analogs will protect against bleomycin-induced pulmonary fibrosis in COX-2(-/-) mice, and investigation of these agents as a novel therapeutic approach to pulmonary fibrotic lung disease in humans may be warranted.