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Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
Papers
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Dietary {alpha}-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation
Stephan Winnik,Christine Lohmann,E.K. Richter,Nicola Schäfer,W L Song,Florian Leiber,Pavani Mocharla,Janin Hofmann,Roland Klingenberg,Jan Borén,Burkhard Becher,Garret A. FitzGerald,Thomas F. Lüscher,Christian M. Matter,Jürg H. Beer +14 more
TL;DR: Dietary ALA diminishes experimental atherogenesis and restricts T cell-driven inflammation, thus providing the proof-of-principle that plant-derived ALA may provide a valuable alternative to marine LC n-3 FA.
Journal Article
The Relationships Among Dose, Effectiveness, and Side Effects
Carlo Patrono,Barry S. Coller,James E. Dalen,Garret A. FitzGerald,Valentin Fuster,Michael Gent,Jack Hirsh,Gerald Juergen Roth +7 more
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Dietary fish oil accelerates the response to coronary thrombolysis with tissue-type plasminogen activator. Evidence for a modest platelet inhibitory effect in vivo.
TL;DR: Fish oils significantly enhance the efficacy of rt-PA in vivo, albeit to a modest extent, and this effect is likely to reflect the demonstrated suppression of TxA2 biosynthesis by fish oils.
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Series Introduction: COX in a crystal ball: current status and future promise of prostaglandin research
TL;DR: Prostaglandins were first discovered by von Euler in the late 1940s to be active principles in semen that induced uterine contractility but was eclipsed in the popular vision by those other stepchildren of Von Euler’s creativity, the catecholamines.
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COX-2, the dominant source of prostacyclin
TL;DR: It is claimed that cyclooxygenase (COX)-1, not COX-2, is the dominant source of prostacyclin (PGI2), but this conclusion was based on experiments using a flawed approach to estimating enzyme activity and PGI2 formation and a selective omission of data in the literature.