G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT
Shuai Yan,Qianqian Zhang,Xiaojing Zhong,Juan Tang,Yuanyang Wang,Junjie Yu,Yi Zhou,Jian Zhang,Feifan（郭非凡） Guo,Yi（刘浥） Liu,Garret A. FitzGerald,Ying（余鹰） Yu +11 more
TL;DR: In this article, the I prostanoid receptor (IP) deficiency inhibited starvation-induced hepatic gluconeogenesis, thus inhibiting the progression of diabetes, whereas hepatic over-expression of IP increased the liver's response to diabetic stresses.
Journal ArticleDOI
Measure for Measure: Biomarker standards and transparency.
TL;DR: Biomarker tests for molecularly targeted therapies might be the key to unlocking the entry gate to precision medicine.
Journal ArticleDOI
The translational therapeutics of prostaglandin inhibition in atherothrombosis.
TL;DR: Prostaglandins, products of the cyclo‐oxygenase (COX) enzymes, can both promote and restrain atherothrombosis and elucidation of the biology of this pathway using diversified approaches is relevant to understanding the implications of substrate rediversion following inhibition of enzymes downstream of COXs.
Journal ArticleDOI
Endogenous prostacyclin and thromboxane biosynthesis during chronic vitamin e therapy in man
TL;DR: The effects of vitamin E on endogenous prostacyclin and thromboxane biosynthesis in man is sought to explore and it is possible that much lower concentrations of a-tocopherol might influence prostaglandin (PG) biosynthesis, as suggested by some animal experiments.
Book ChapterDOI
Novel indices of oxidant stress in cardiovascular disease: specific analysis of F2-isoprostanes.
TL;DR: The development of methods to measure specific isoprostanes affords a unique opportunity to investigate both the role of oxidant stress as a mechanism of disease in vivo and to select rational doses of putative antioxidant drugs and vitamins for evaluation in human disease.