G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Targeted Deletions of Cyclooxygenase-2 and Atherogenesis in Mice
Yiqun Hui,Emanuela Ricciotti,Irene Crichton,Zhou Yu,Dairong Wang,Jane Stubbe,Miao Wang,Ellen Puré,Garret A. FitzGerald +8 more
TL;DR: Macrophage–COX-2, primarily a source of thromboxane A2 and prostaglandin (PG)E2, promotes atherogenesis and exerts a restraint on enzyme expression by lesional cells suggestive of vascular smooth muscle cells, a prominent source of atheroprotective prostacyclin.
Journal ArticleDOI
Selective and nonselective inhibition of thromboxane formation
TL;DR: Enhanced prostacyclin synthesis may be an important component of the platelet inhibitory actions of thromboxane synthase inhibitors in man.
Journal ArticleDOI
Niacin, an old drug with a new twist.
TL;DR: It remains to be determined whether niacin may have clinical utility in particular subgroups, such as statin intolerant patients with hypercholesterolemia or those who cannot achieve a sufficient reduction in LDLc, and whether a potentially beneficial effect of niacIn is confounded by DP antagonism in HPS2-THRIVE.
Book ChapterDOI
Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: a detailed HPLC/MS/MS method.
TL;DR: A robust method for the routine quantitation of a selected group of urinary eicosanoid metabolites of interest to cardiovascular research in human and mouse is described and discussed.