G
Garret A. FitzGerald
Researcher at University of Pennsylvania
Publications - 573
Citations - 64984
Garret A. FitzGerald is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Prostacyclin & Thromboxane. The author has an hindex of 127, co-authored 547 publications receiving 60448 citations. Previous affiliations of Garret A. FitzGerald include French Institute of Health and Medical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo
Elizabeth J. Westgate,Yan Cheng,Dermot F. Reilly,Thomas S. Price,Jacqueline A. Walisser,Christopher A. Bradfield,Garret A. FitzGerald +6 more
TL;DR: Key components of the molecular clock regulate the response to a thrombogenic stimulus in vivo, and together with the influence of these genes on blood pressure may contribute to the diurnal variation in cardiovascular events observed in humans.
Journal ArticleDOI
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height
Matthew B. Lanktree,Yiran Guo,Yiran Guo,Muhammed Murtaza,Joseph T. Glessner,Swneke D. Bailey,N. Charlotte Onland-Moret,Guillaume Lettre,Halit Ongen,Ramakrishnan Rajagopalan,Toby Johnson,Haiqing Shen,Christopher P. Nelson,Christopher P. Nelson,N. Klopp,Jens Baumert,Sandosh Padmanabhan,Nathan Pankratz,Nathan Pankratz,James S. Pankow,Sonia Shah,Kira C. Taylor,John Barnard,Bas J M Peters,Cliona M. Maloney,Maximilian T. Lobmeyer,Alice Stanton,M. Hadi Zafarmand,Simon P. R. Romaine,Amar J. Mehta,Erik P A Van Iperen,Yan Gong,Thomas S. Price,Erin N. Smith,Cecilia E. Kim,Yun Li,Folkert W. Asselbergs,Larry D. Atwood,Kristian M. Bailey,Deepak L. Bhatt,Florianne Bauer,Elijah R. Behr,Tushar Bhangale,Jolanda M. A. Boer,Bernhard O. Boehm,Jonathan P. Bradfield,Morris Brown,Peter S. Braund,Peter S. Braund,Paul Burton,Cara L. Carty,Hareesh R. Chandrupatla,Wei Chen,John M. C. Connell,Chrysoula Dalgeorgou,Anthonius de Boer,Fotios Drenos,Clara C. Elbers,James C. Fang,Caroline S. Fox,Edward C. Frackelton,Barry D. Fuchs,Clement E. Furlong,Quince Gibson,Christian Gieger,Anuj Goel,Diederik E. Grobbee,Claire E. Hastie,Philip Howard,Guan-Hua Huang,W. Craig Johnson,Qing Li,Marcus E. Kleber,Barbara E.K. Klein,Ronald Klein,Charles Kooperberg,Bonnie Ky,Andrea Z. LaCroix,Paul N. Lanken,Mark Lathrop,Mingyao Li,Vanessa Marshall,Olle Melander,Frank D. Mentch,Nuala J. Meyer,Keri L. Monda,Alexandre Montpetit,Gurunathan Murugesan,Karen Nakayama,Dave Nondahl,Abiodun Onipinla,Suzanne Rafelt,Suzanne Rafelt,Stephen Newhouse,F. George Otieno,Sanjey R. Patel,Mary E. Putt,Santiago Rodriguez,Radwan Safa,Douglas B. Sawyer,Pamela J. Schreiner,Claire L. Simpson,Suthesh Sivapalaratnam,Sathanur R. Srinivasan,Christine Suver,Gary Swergold,Nancy K. Sweitzer,Kelly A. Thomas,Barbara Thorand,Nicholas J. Timpson,Sam Tischfield,Martin D. Tobin,Mac Iej Tomaszweski,Mac Iej Tomaszweski,W. M. Monique Verschuren,Chris Wallace,Bernhard R. Winkelmann,Haitao Zhang,Dongling Zheng,Li Zhang,Joseph M. Zmuda,Robert Clarke,Anthony J. Balmforth,John Danesh,Ian N. M. Day,Nicholas J. Schork,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Christian Delles,David Duggan,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Marten H. Hofker,Steve E. Humphries,Mika Kivimäki,Debbie A Lawlor,Kandice Kottke-Marchant,Jessica L. Mega,Braxton D. Mitchell,David A. Morrow,Jutta Palmen,Susan Redline,Denis C. Shields,Alan R. Shuldiner,Patrick M. A. Sleiman,George Davey Smith,Martin Farrall,Yalda Jamshidi,David C. Christiani,Juan P. Casas,Alistair S. Hall,Pieter A. Doevendans,Jason D. Christie,Gerald S. Berenson,Sarah S. Murray,Thomas Illig,Gerald W. Dorn,Thomas P. Cappola,Eric Boerwinkle,Peter S. Sever,Daniel J. Rader,Muredach P. Reilly,Mark J. Caulfield,Philippa J. Talmud,Eric J. Topol,James C. Engert,Kai Wang,Anna F. Dominiczak,Anders Hamsten,Sean P. Curtis,Roy L. Silverstein,Leslie A. Lange,Marc S. Sabatine,Mieke D. Trip,Danish Saleheen,John F. Peden,Karen J. Cruickshanks,Winfried März,Jeffrey R. O'Connell,Olaf H. Klungel,Cisca Wijmenga,Anke-Hilse Maitland-van der Zee,Eric E. Schadt,Julie A. Johnson,Gail P. Jarvik,George J. Papanicolaou,Struan F.A. Grant,Patricia B. Munroe,Kari E. North,Nilesh J. Samani,Nilesh J. Samani,Wolfgang Koenig,Tom R. Gaunt,Sonia S. Anand,Yvonne T. van der Schouw,Nicole Soranzo,Garret A. FitzGerald,Alexander P. Reiner,Robert A. Hegele,Hakon Hakonarson,Brendan J. Keating +202 more
TL;DR: It is shown that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait.
Journal ArticleDOI
Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations.
TL;DR: Prostacyclin synthesis may be important for limiting thrombotic events in patients who are at an increased cardiovascular risk, and further studies are necessary to clarify the relative risk-to-benefit ratio of COX-2 inhibition in patients at increased risk for cardiovascular events, and the effects of concomitant aspirin therapy.
Journal ArticleDOI
Phosphorylation of the Thromboxane Receptor α, the Predominant Isoform Expressed in Human Platelets
TL;DR: Protein kinase C played a more important role in agonist-induced phosphorylation of native TPα in human platelets than in human embryonic kidney 293 cells overexpressing recombinant TPα, and TPα was the only isoform detectably translated inhuman platelets.
Journal ArticleDOI
Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh.
TL;DR: Gh is expressed in platelets and vascular cells and may associate with both TP isoforms, however, stimulation of TP iso forms results in differential activation of downstream signaling pathways via this novel G protein.